=Wounds complicated with fracture and depression on the cerebrum.=—Such wounds are most serious, and the prognosis must be very unfavorable. They must not be judged of by comparison with cases of fracture with depression caused by such injuries as are usually met with in civil practice. The severe concussion of the whole osseous sphere by the stroke of the projectile, the bruising and injury to the bony texture immediately surrounding the spot against which it has directly impinged, as well as the contusion of the external soft parts, so that the wound cannot close by the adhesive process, constitute very important differences between gunshot injuries on the one side, and others caused by instruments impelled solely by muscular force on the other. So, also, the injury to the brain within, and its investments, is proportionably greater in such injuries from gunshot. The experience of the Crimean campaign shows that, when these injuries occurred in a severe form, they invariably proved fatal. Of seventy–six cases treated, where depression only, without penetration or perforation, existed, fifty–five proved fatal, twelve were invalided, and nine only were discharged to duty. In the twenty–one survivors, the amount of depression is stated in the history of the campaign to have been slight, though unmistakable, and all except one recovered without any bad symptom. Of eighty–six other cases where perforation or penetration of the cranium occurred, all died. =With penetration of the cerebrum.=—It is obvious that, where a projectile has power not only to fracture, but also to penetrate the cranium, it will rarely be arrested in its progress near the wound of entrance. Either splinters of bone, or the ball, or a portion of it will be carried through the membranes into the cerebral mass. Sometimes a ball, if not making its exit by a second opening in the cranium, will lodge at the point of the cerebral substance opposite to that of its place of entrance; but the course a projectile may follow within the cranium is very uncertain.