At the very commencement of the disease, a globule of Apis 3 is sufficient to cut short the disease so that the patient feels easy, and sleeps quietly. During this slumber, fever, pain and tenesmus disappear, and the patient wakes with a feeling of health. If this should not take place in three hours, owing to the more advanced state of the disease, another dose of Apis is required, after which the patient soon feels well. If the dysenteric disease has had a chance to localize itself, and to assume a higher degree of intensity, it becomes necessary to excite the organic reaction all the more frequently. Under these circumstances we repeat the medicine every hour, or every two or three hours, one globule at a time, until all further medication has become unnecessary. It is well known that epidemic diarrhœa, viz., a diarrhœa resulting from peculiar alterations of the normal condition of the atmosphere, earth, water, indispensable food, or from other still unknown elementary influences inevitably acting upon every body, commences in the form of a simple, apparently unimportant diarrhœa; that it gradually increases in intensity as the processes of nutrition and sanguification become more deeply disturbed, and that it finally terminates in life-destroying cholera. All these different stages of diarrhœa, whether with or without vomiting, watery or papescent, of one color or another, with or without pain, with or without fever, have yielded readily, safely and thoroughly to Apis in my hands. I must except, however, cholera of the epidemic form, where I have not yet been able to try Apis for want of opportunity. As far as my personal observations go, I am disposed to affirm that the best mode of effecting a good result, is to give Apis 3 and Aconite 3, in alternation, one drop of each preparation well shaken in a bottle containing twelve tablespoonfuls of water, and giving a tablespoonful every hour or three hours, if the danger is great, and in milder cases a full drop alternately morning and evening. This treatment is continued until an improvement sets in, after which the organic reaction is permitted to develope itself, which will terminate in a few hours or days, according as the disease is more or less violent, and assistance was sought more or less early, in the perfect recovery of the patient. This end is not always attained with equal certainty and rapidity, if Apis is not given in alternation with Aconite. In such a case, Apis alone often develops a powerful reaction, which is avoided by the alternate use of Aconite. Wherever the case is urgent, and it is important to shorten the durations of the organic reaction, the two remedies should be given in alternation. In most cases I have seen a few alternate doses give rise to a pleasant perspiration, speedily followed by quiet sleep and recovery on waking. May we not expect the same result at the commencement of Asiatic cholera, and thus arrest the further development of the disease?