The first point of importance to which I wish to call your attention is in regard to the action of the bowels. Some of you may remember that even that great surgeon, Sir Arbuthnot Lane, has recently emphasized the fact that one of the terminal results of intestinal stasis may be cancer. This may seem strange, but it would surprise you if you knew how very commonly there was imperfect intestinal excretion, or intestinal stasis, as it is now called, in these subjects; indeed, I might almost say that it is the rule, and that this assuredly plays a most important part in the auto-intoxication which leads up to cancer; in fact, I almost feel like saying that the toxins produced by the millions of micro-organisms generated through intestinal stasis and fecal putrefaction are the real, incidental cause of cancer. Under a perfect vegetarian diet there is less likelihood of trouble in this direction, but even then there is necessity of watching continually, that there may be at least, one, full, free movement of normal character, daily, after breakfast. In many cancer patients I have secured this by having the entire potato eaten, skin and all, whether boiled or baked; by this means also one gets the full value of the inner layer of skin, which contains the mineral salts so necessary to the economy, which are entirely lost when the potatoes are peeled before boiling; so that potatoes should always be cooked in their skins, even if the outer layer is stripped off afterwards. But the regulation of the bowel action should not be left to the judgment and action of patients, with a spasmodic use of remedies, and with alternate constipation and purgation; the physician himself should carefully guide and direct the proper treatment frequently enough to secure perfect results. Of course each one may have their own ideas and methods, but I have long used with the best results the remedies which you have often heard me order in this clinic. Thus, at the beginning of treatment, and often on the same days of many succeeding weeks, I give ℞ Ext. Colocynth. Co., Mass Hydrarg ‾aa‾ gr. x Pulv. Ipecac gr. ‾ij‾ M. Div. in Capsules No. IV. Sig. Take two at night and two on the second night after. For continuous use, or in the nights between these, I have long used a compound Cascarin tablet (℞ Podophylin, Aloin, Cascarin ‾aa‾ gr. ¼) one or more each night, or have depended on the Cascara in a mixture of which I shall shortly speak. I do not like the action of salts or laxative mineral waters in these cases, and, of course, enemata are entirely useless to secure real, effective liver and intestinal action, and should be used only in an emergency.