The large number of cases of endocarditis among the Carnivora, Accipitres, Anseres and Marsupialia is noteworthy and can hardly be explained by other argument than a special vulnerability of this organ in these groups. However, the unusual number of cases in our only native marsupial, the opossum, seems worthy of a special note since ten of the twelve instances in the order Marsupialia affected this particular animal. When seen these ten cases were acute in five instances, subacute in three and chronic in two. The Streptococcus pyogenes was isolated in three of the five acute cases; bacteriology of the others was negative or not done. All of the acute and one of the subacute cases were combined with some evidence of general septicemia. The type of lesion was in no way peculiar, unless the facts that all were vegetative when acute and markedly deforming when chronic, be noteworthy. In two chronic aortic cases the valvular orifice was almost closed, yet the left ventricle could not be considered as greatly hypertrophied and no dilatation existed. In one acute aortic and mitral case, general dilatation existed. The mitral was involved nine times, three times alone, four times with the aortic, once each with the tricuspid and pulmonary. Once the vegetations were limited to the mural endocardium. Nine of these animals came from one enclosure over a period of two and a half years, during which time other opossums died from similar bacterial infections (pneumonia) despite repeated cleansing of the place. No unusual number of cases of this or similar kinds occurred elsewhere in the Garden at this time, but it would seem that we had in this cage a continued bacterial infection. UNUSUAL PERICARDIAL CHANGES. The appearance of a stiff gelatinous exudate in the pericardial sac has attracted our attention on ten occasions (8 birds, 2 mammals). The substance seems quite homogeneous and almost entirely acellular. One specimen became solid on heating and another became turbid when put into Kaiserling’s fluid. In two cases bacterial cultures were made; nothing grew. It has not been associated with tuberculosis or tumors nor has any one pathological lesion more than another appeared to accompany it.