From the Diversity of Pains and other Symptoms in the Gout, it appears that these saline Particles are sometimes salt and pungent, sometimes more volatile, sharp and burning. That the mucilaginous Humour is frequently acid and corrosive in the Gout, appears from hence, that this Liquor is neither so easily coagulated, nor acquires so great a Degree of Viscidity by any other Mixture as with austere Acids, and from the Obstinacy and Duration of the Pain. It is frequently observed, that upon the Approach of a Fit, People complain of sowre Belchings, Wind, and vomit acid Humours, so that hypochondriac People, and such as are subject to the Gravel, are most apt to be seized with this Distemper; this may afford a good Reason why not only the drinking of acid Wines bring on a Fit in gouty Persons, but originally occasion the Gout in such Persons as frequently drink them. The Mixture of Wine with the Mucilage plainly evinces, that the acid Particles of the Wine give a Disposition to the Distemper, for it caused a greater Coagulation of the Mucilage than Oyl of Vitriol, whence easily appears what Mischief it may do to gouty Persons. SECT. 3. How this sharp acid Humour comes to be secerned in the Glands, seems to want Explanation, and this I judge to be in the following Manner. The Blood being first imbued with a sufficient Quantity of these saline heterogeneous Particles, which it receives from the corrupted Chyle, is by Degrees disturbed in its Motion, and the Fibres of the Nerves begin to be sensibly irritated, so as to cause irregular Motions of the animal Spirits. The Blood itself is thickned, because these saline and viscid Particles get into the small Ramifications of the Arteries, and occasion Obstructions there; by this Means the natural Functions and Secretions of the Humours, especially in the Glands, are disturbed, and proceed slower; and accordingly for some Time before the Fit, we find Complaints of Crudities in the Stomach, a swelling and Heaviness of Body, and Weakness and Numbness of the Limbs, which increase daily till the Fit is formed. At length the Blood, by continued Irritations, being put into more violent Motions, drives these saline heterogeneous viscid Particles through the obstructed Capillaries into the glandular Vesicles, whence without doubt the Juices there secerned, especially that of which we are speaking, _viz._ the Mucilage in the Glands in and about the Joints, is not only plentifully stored with these acid corrosive Salts, becomes more viscid and ropy, but also very corrosive and poignant; and while it irritates and corrodes the adjoining Membranes and Tendons, not only causes violent Pains, but also since by the Contraction of the Nerves the Blood cannot move so freely through the smallest Vessels, the Fibres are distended, and an inflammatory Tumor frequently succeeds. SECT. 4.