The first and third provers of this drug, on a voyage to Brazil, in 1842, had both been attacked with the lepra. Under homœopathic treatment they seemed both to have got well, though one might have inferred from the gravity of their symptoms, that they had been palliated rather than cured. The frightful symptoms of compression of the spinal marrow, which supervened in the case of one of the provers, point to the Assacù as a powerful remedy for various forms of myelitis. The symptoms of nervous excitement, the twitching, the irritability of the temperament exhibited by all the provers, favor the doctrine that the lepra is a particular lesion of the nervous system. If the exanthems and the insensibility of the skin characteristic of the lepra, have been less marked in our provings, it is undoubtedly because these phenomena belong to some chronic form which a continued use of the drug and a real poisoning are alone capable of producing. These four provings have been instituted with a single drop of the fifth attenuation. It is our rule to avoid repeating the dose lest the chronological succession of the symptoms which we regard as important, should be disturbed. We do not believe that repeated doses can do much good, and if a prover should not experience any effects from one dose, we should prefer dropping this proving, and resort to some other drug, to which his organism should be more sensible. First prover: Aug. Joly, 29 years of age, bilious-nervous temperament, healthy constitution. _First day._—Took one drop of the 5th attenuation at ten o’clock at night. 1. One hour after, itching at the ribs and sternum, at the biceps and the posterior parts of the right arm. Doughy mouth, in the morning, on waking. Dreams about a ball, about houses in process of erection. In the morning, itching at the arms, legs, outer parts of the tibia. 5. The upper and lower eyelids are inflamed and blueish. Itching at the right arm, at the lower and inner portion of the humerus, owing to a little pimple which is forming. Taste of blood in the mouth. Whizzing in the ears, especially the right. Clusters of miliary pimples on the back, arms, legs and chest. 10. Irritated by the least contrariety. Desire to vomit, sick stomach. Rheumatic pain at the left arm. He looks weary as if he had been carousing all night, though he slept well all night. Pinching at the right side of the tongue. 15. Lancination in the canal of the urethra. Prickling around the eyes, and especially around the right one. Sensation as if small pimples would break out on the inside of the eyelids. Nervous beating in the eyelids. Rheumatic pain at the sacrum, especially when stooping. 20. Contusive pain at the lumbar region. Miliary eruption in the joints.