As two opposite methods of dealing with rabies had been ably supported by Professors Roux and Fleming, I called attention to the fact that nothing had been said in the discussion of the sufferings necessarily inflicted upon animals where the Pasteur method advocated by Professor Roux was adopted, and I stated that in a Pasteur Institute dogs were kept in a state of madness. I therefore recommended that Municipal and County Regulations, with their excellent results, as shown by Professor Fleming of London, and Professor Ostertag of Berlin, should be adopted rather than Pasteurian methods. In illustration of the sufferings of dogs when made mad, I referred to my visit to the Rue Dutôt on June 2, 1889, where, after inspecting the Hall of rabbits, guinea-pigs, and pigeons used in experiments for rabies, anthrax, etc., I went to the cages of three dogs also used for experiments in rabies, who were in various stages of madness, one dying after its ten days’ agony; a second in the full fury of madness; a third in frantic terror clinging to the bars of his cage, imploring to be let out. Professor Roux’s statement in opposition to my recommendation of the humaner methods of dealing with rabies seemed to infer that dogs were not rendered mad in a Pasteur Institute or in dealing with rabies. But when I stated to the Professor that I had myself seen this series of three dogs being made mad, he replied: ‘Oh, you might have seen a great many more, but they are not to inoculate people.’ Now, it is well known from experience that it is too dangerous to inoculate direct from the dog to the human being. But the fact that dogs are constantly made mad for experiment in the Pasteur Institute, or in any institute that adopts Pasteurian methods, should be honestly acknowledged, not evaded. The fact that this frightful disease of rabies is kept up for purposes of experiment, although the virus be transmitted in changed form through other animals for the inoculation of human beings, is in itself a grave fact, and it bears directly on the point which I dwelt on at the Congress--viz., that in choosing the method of protecting humanity from a rare but frightful disease, the method that does not involve sufferings to animals should be adopted by a Christian nation. SCIENTIFIC METHOD IN BIOLOGY CONTENTS PAGE INTRODUCTION 89 CHAPTER I THE GROWTH OF CONSCIENCE 91 CHAPTER II CONSCIENCE IN MEDICINE 95 CHAPTER III THE MORAL ELEMENT IN RESEARCH 98 CHAPTER IV RIGHT AND WRONG METHOD 101 CHAPTER V THE NECESSITY OF MEDICAL RESEARCH 104 CHAPTER VI