Still more will this inflammation persist, if it have gone to the extent of forming new parts, whether phlegmons or pustules. The intensity of the inflammation may be somewhat moderated, but it cannot be conquered now as at the commencement, or during the first period, or that of invasion. We cannot, from our own experience, speak favourably of the remedy in the second, or eruptive stage. It did not answer our expectations, though employed in subjects apparently the best constituted to derive the good effects proposed from it. We must at the same time grant, that it was complicated with other remedies. Of topical bleeding, we are unable to speak, not having seen it tried. In this period of the disease, it must be of very difficult execution. Still less reason have we to boast of the good effects of purging. Though the skin may for a while be relieved by the watery secretions from the intestinal canal; yet the irritation of the latter, consequent on purging, is soon communicated to the cutaneous surface with the effect of aggravating the eruption. To the class of stimuli or stimulating diaphoretics, the same objections apply with increased force. As on the one hand, in cases of high fever, seeming to call for great depletion, the surfaces are often not relieved by general bleeding, but retain their own vitality; so on the other, in cases of apparent prostration, and feebleness of circulation, they often retain all their morbid activity, and will of course be materially injured by stimulation, either of hot air to the skin, or heating drinks to the gastric and intestinal surface. Of the various diaphoretics employed, we had reason to be least dissatisfied with the combination of opium and ipecacuanha in small doses. In some few cases, tartrate of antimony and cream of tartar, dissolved in rice or barley water, and the solution used as a drink, seemed to be beneficial. Several grains of the former were thus taken in the 24 hours, without its producing vomiting or purging. But in very many other instances of the disease, this medicine had no ameliorating effects. Calomel alone, or in combination with opium, was given, and in a few cases caused _ptyalism_. We did not lose persons thus affected, but we cannot speak with any confidence of the propriety of the treatment.