These theosophic vagaries reached their climax in Neo-Platonism, which was founded toward the end of the second century of the Christian era by the Alexandrian porter, Ammonius (175 to 242), and was further elaborated by Plotinus (204 to 269). This religious, philosophical system is of very particular interest in the history of medicine in that, in the first place, it stands in direct opposition to the physico-mechanical conception of disease, and, explaining sickness from a theistic standpoint as a logical consequence, rejects the treatment of disease by professional physicians. Now this theistic conception of disease was based primarily upon the assumption that the universe is filled with countless demons, spirits which, altho essentially superior to man, are inferior to God. Such a demon was supposed to be the “spiritus rector” of all terrestrial occurrences, especially all evil events were attributed to him. ὂτι αὐτοὶ αἳτιοι γιγνόμενοι τῶν Περὶ τὴν γῆν καθημάτων, οἷον λοιμῶν, ἀΦοριῶν, σεισμῶν, αὐχμῶν Καἳ τῶν ὁμοίων (Porphyrius de Abst., lib. 2, 40). As the demons played havoc with the condition of the human body, protection against them could not be expected from a professional physician, but only from some one well versed in all their tricks and devices, and, therefore, alone able to punish them thoroughly for their mischievous behavior. This taming of the demon could be accomplished in various ways. Porphyrius enumerates three methods of gaining an influence over the host of demons. The first and principal method (theosophy) attempted to attain the most intimate union with God. Prayer, abstraction of all thought from things earthly, and absorption in God were supposed to be the means of participation in certain divine powers. An individual thus favored was enabled in a trice to restore health to incurable patients, such as the blind, the deaf, and the lame, and even the power of raising the dead was conferred upon him. However, the acquisition of such extraordinary powers demanded certain qualifications of a rather exacting and terrestrial character. It was incumbent upon such an applicant for these special gifts to abstain from the use of meat, and, above all, from the society of women. How many were deterred by these fastidious requirements from choosing the career of a famous man of miracles we do not know. Nothing is reported on this subject by the pillars of Neo-Platonism (as, Plotinus, Porphyrius, Damascius, Jamblichus), nor do they state whether they themselves absolutely abstained from meat and from the society of women. Theurgy was the second method of counteracting the evil influence of demons. In this way good demons were urged by prayer and offerings to ward off disease or other misfortune.