The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economyHeadland, Frederick William
Science
The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economy
Headland, Frederick William
Therapeutics
The subject of this Proposition divides itself naturally into three
parts. We shall have to consider--1. What is the nature, and what the
function, of the gastric and intestinal secretions. 2. The laws of this
process of Endosmotic absorption, and how they are fulfilled in this
case; and, 3. The mode in which the great majority of medicines are
reduced to a state of solution, which is necessary before they can be
absorbed.
The process of stomach-digestion has been cleared up of late years by
the decisive experiments of Spallanzani and Réaumur, of Tiedemann and
Gmelin, and of Dr. Beaumont of Canada.
Immediately that a substance touches the mucous surface of the stomach
it causes the copious outpouring of a thin fluid, which is secreted by a
glandular apparatus. This gastric juice is highly acid, and contains
besides a peculiar nitrogenous substance called Pepsin. Dr. Prout
thought that the reaction was due to free Hydrochloric acid. But it
seems more likely that it is due to Lactic acid. Such at least is the
opinion entertained both by Liebig and Lehmann. Now the result of the
action of this fluid is to dissolve down the solid materials of the
food, or other substances presented to it, reducing them to a thin
watery pulp. This pulp is then mainly absorbed; and that which is not
taken up through the coat of the stomach is absorbed in the earlier
portion of the intestinal canal. I shall have to treat of Aliments as
one of the orders of Restorative Hæmatics.
We are now concerned with medicines in general. The same juice is poured
out to receive them. Such as are dissolved by it are immediately
absorbed. Some other matters may be rendered soluble by the agency of
the Bile and Pancreatic juice which are poured out into the middle of
the Duodenum. The former is an alkaline fluid, containing carbonate of
Soda. The Pancreatic juice is also said to be alkaline. That the
stomach is absorbent may be proved by the experiment of placing a
ligature round the intestine of a dog, just below the pylorus. It is
then found that soluble substances placed in the stomach pass rapidly
from it into the circulation. It is probable that all substances which
are easily dissolved pass through the coats of the stomach. That the
surface of the intestines is absorbent may be proved by the
disappearance of enemata thrown into them. Liebig states that a solution
of common salt, in the proportion of one part to eighty of water,
disappeared so completely in the rectum that an evacuation one hour
afterwards was found to contain no more than the usual proportion of
salt. (_Animal Chemistry_, _p._ 77.)
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