First:--When it appears in a natural form, without the agency of contagion or inoculation, dryness of the skin, entire omission of insensible perspiration, starring of the coat. Sometimes slight discoloring can be observed about the forehead and lower part of the ears. Drowsiness, want of lustre in the eye, slight swelling on the inside of the hind legs, extending up to the bu-boa. This condition of things may continue for several days, and will be followed by enlargement between the legs. The inflammation incident to this may entirely subside, or it may continue to enlarge, and break out in ulcers on the _lactiles_ of the lymphatic, which accompanies the large veins. In the last case it has appeared in the form of Farcy. This being the case, the countenance assumes a more cheerful look, and the animal otherwise shows signs of relief from the discharges of poisonous matter. If it remain in this state, death is not generally the result. If the system be toned up it will sometimes heal, and the animal will seem to be in a recovering state of health. Yet, from watching the symptoms and general health of the animal afterwards, you will be convinced that the disease is only checked, not eradicated. Acting in the system, it only waits a favorable opportunity to act as a secondary agent in colds, general debility, or exposure, when it will make its appearance and produce death. But in the first case, as shown by the swelling in the hind legs, if the swelling disappear, and general debility of the system continues; if the eyes grow more drowsy, and discharge from the lower corners; and if this is followed by discharge from the nostrils, slight swelling and hardening of the sub-maxillary glands, which are between the under jaws, then it is clearly developed glanders. All the glands in the body have now become involved or poisoned, and death must follow in the course of ten or fifteen days, as the constitution of the animal may not be in a condition to combat the disease. If this disease be annoyed by inoculation from the _farcy heads_ of farcied animals into suppurating sores on other animals, it will be very slow in its progress, especially if it attack the other in a region remote from the lymphatic. If in a saddle-gall, it will make sores very difficult to heal. If there is any such thing as checking the disease in its progress, it is in these three cases.