The fourth and fifth weeks I found to be immeasurably the most difficult to manage. By the sixth week the system had become somewhat accustomed to the denial of the long-used stimulant. At any rate, though no abatement of the previous wretchedness was apparent, it certainly seemed less difficult to endure it. It is at this stage of the process that I regard the advice and encouragement of a physician as most important. He may not indeed be able to do much in direct alleviation of the pain incident to the abandonment of opium, for I suspect that little reliance can be placed upon the medicines ordinarily recommended. The system has become accustomed to the stimulant to an exorbitant degree; the suffering is consequent upon the effort to accustom the system to get on without it. Other kinds of stimulants, like spirits or wine, will afford a slight relief for a few days, especially if taken in sufficiently large quantities to induce sleep. It is the sedative qualities of the opium that are chiefly missed, for as to excitement the patient has quite as much of it as he can bear. For this reason malt liquors are preferable to distilled spirits--they stupefy more than they excite. But to malt liquors this serious objection exists, they tend powerfully to aggravate all disorders of the liver. This tendency the reforming opium-eater can not afford to overlook, for no one effect of the experiment is more distressing than the marvellous and unhealthy activity given to this organ by the process through which he is passing. The testimony of all opium-eaters on this point is uniform. For months and even years this organ in those who have relinquished the drug remains disordered. When in its worst state, the use of something bitter, the more bitter the better, is exceedingly grateful. The difficulty lies in finding any thing that has a properly bitter taste. Aloes, nux vomica, colocynth, quassia, have a flavor that is much more sweet than bitter. These serious annoyances from the condition of the liver, as well as those arising from the state of the stomach and some of the other organs, may be somewhat mitigated by the skill of an intelligent medical man, who, even if he happens to know little about the habit of opium-eating, should know much as to the proper regimen to be observed in cases where these organs are disordered.