[Sidenote: _Ga. loc. affect. 6 Felix Platerus de causis febrium. pag. 63. 65 66. &c. Mercatus. Fernel. patholog. li. 6, cap. 16_] _Galen_ in the former place declareth this by the example of a mad dogge, whose venom being receiued of us, although but by the foame of his mouth, will remaine sometimes sixe moneths within our bodies vndiscouered, and then hauing gotten more strength and ripenes vnto it selfe, and opportunitie of conuaying his euil quallity vnto the parts, breaketh forth to open view by diminishing or peruerting the faculties of those parts. I had once a patient in Kent who feeding vpon a mad hogge which hee had killed for couetousnesse sake, found himselfe distempered therewith at the first, but within fiue or sixe moneths after grew suddenly to be starke madde, and before his death, being by Phisicke restored to some reasonable vnderstanding, he confessed the eating of that hogge to haue beene the true cause of his disease. Diuers reasons may be yeelded of this as well as of the fits of intermittent agues of _Epilepsies_, of sweating, &c. which oftentimes haue their due recourse by the yeare, moneth, weeke, day or houre, according to the nature of the humor: which being crude expecteth his concoction in our bodies and giues no signe of his presence vntill such a proportion of it be digested and resolued into vapours, as for the offẽce therof the part affected is not able to brooke and for the weaknesse of the expulsiue facultie not able to auoide out of the bodie: but filling the vaines, arteries, and the habit of the body, is communicated to the principall parts; diminishing or deprauing their functions so long, vntill that portion of vapours be discussed through naturall heate: and ceasing againe so long vntill by fermentation and concoction, another portion of the corrupt humor shall be digested. [Sidenote: _Quia multum. Quia prauum. Quia insuetũ._] The vniformitie of this humor and of the heate of concoction causeth the vniformitie of fits. And this is the cause of the due periods or circuites which oftentimes are obserued in this disease, whereof wee haue spoken before: 2 according also to the condition of the part affected, which seruing as an euacuatorie to the whole bodie, is accustomed to such kind of humors and therefore can endure them better then other parts can. And this is another cause why this humor giues no signe of his presence vntill it may communicate with the principall partes: which are soone offended either with the plenty of those vapours, or with the malignity, or with the vnwonted and vnaccustomed approach of them.