The Karens and other hill-tribes are so fearful of smallpox that when it comes near their villages, they all flee to the mountains. Smallpox had broken out in a Lāo village near a Karen settlement. The settlement was at once deserted. Meanwhile the news of the efficacy of vaccination had reached the Lāo village, and they sent a messenger with an elephant to beg me to come and vaccinate the entire community. Two young monks came also from an adjoining village, where the disease was already raging. These two I vaccinated at once, and sent home, arranging to follow them later when their pustules should be ripe. From them I vaccinated about twenty of the villagers. During the following week the Karens all returned, and in one day I vaccinated one hundred and sixty-three persons. It was a strange sight to see four generations all vaccinated at one time—great-grandfathers holding out their withered arms along with babes a month old. Success such as this was naturally very flattering to one’s pride; and “pride goeth before a fall.” I had kept the Prince informed of the success of my attempt, and naturally was anxious to introduce vaccination into the palace. The patronage of the palace would ensure its introduction into the whole kingdom. Having a fine vaccine pustule on the arm of a healthy white infant boy, I took him to the palace to show the case to the Prince’s daughter, and to her husband, who was the heir-apparent. They had a little son of about the same age. The parents were pleased, and sent me with the child to the Prince. As soon as he saw the pustule, he pronounced it genuine, and was delighted. His younger daughter had lost a child in the epidemic of the year before, and the family was naturally very anxious on the subject. He sent me immediately to vaccinate his little grandson. I returned to the palace of the son-in-law, and very carefully vaccinated the young prince on whom so many hopes were centred. I watched the case daily, and my best hopes seemed realized. The pustules developed finely. All the characteristic symptoms appeared and disappeared at the proper times. But when the scab was about to fall off, the little prince was taken with diarrhœa. I felt sure that a little paregoric or some other simple remedy would speedily set the child right, and I offered to treat the case. But half a dozen doctors—most of them “spirit-doctors”—were already in attendance. The poor child, I verily believe, was dosed to death. So evident was it that the unfortunate outcome could not have been the result of vaccination, that both the parents again and again assured me that they entertained no such thought. But all diseases—as was then universally believed among the Lāo—are the result of incurring the displeasure of the “spirits” of the family or of the clan. The “spirits” might have taken umbrage at the invasion of their prerogative by vaccination.