A.D. 1472, a comet was seen. The year following, 1473, excessive heat and drought prevailed, which persisted for three years. About this period, 1474, the city of Valencia suffered from a severe epidemic. Luis Alcanyis, a famous Valencian physician, published a treatise in the Limosin language (that of the Troubadours), without giving either the place of printing or the year of publication; but it seems that he flourished about this period (1474), and that his treatise was written in consequence of the epidemic under notice: it was entitled, ‘Regiment preservatiu é curatiu de la Pestilencia, compost per Mestre Luis Alcanyis, Mestre en Medicina.’ A.D. 1475–76, the Danube was fordable in Hungary, and swarms of locusts destroyed all vegetation there and in Poland. The second pestilence, which devastated the island of Mallorca, according to the authority of Don Vincente Mut, occurred. A Board of Health was formed by the governor of Mallorca, Don Berengario Blanels, in order to prescribe rules for government and remedial measures. This ‘Morbeira,’ or Board of Health, was composed of a magistrate, a knight, a physician, a surgeon, a tradesman, and a merchant. Quarantine for forty days was established. In this year there was published a work entitled ‘De Epidemiâ et Peste, Magistri Vallestii Tarentini, Artium Medicinæque Doctoris eximii,’ which was translated by Dr. Juan Villar into the Castilian language. In the latter year (1476), the Council of One Hundred ordered an imprecatory chapel to be consecrated at St. Roque, in consequence of the prevalence of a terrible plague at Barcelona, which lasted from the 27th of March until the 13th of November. On the 13th of July in the same year, a solemn procession took place, in which were exhibited the bodies of St. Severus and St. Innocent. A.D. 1477, in the reign of their Catholic majesties Don Fernando de Aragon and Doña Isabel de Castilla, there broke out a wretched pestilence of leprosy, which may be said to have prevailed epidemically, so numerous were the cases. The duty of examining those affected, and of expelling them from the cities and villages, was a task exclusively imposed on the priests, in accordance with divine authority, as laid down in Leviticus chap. xiii. Epidemic pestilence, attended with bubo, prevailed in Italy, and raged without interruption until 1485. Swarms of locusts committed great ravages in various parts of the South of Europe, from the year 1478 until 1482. Within this period, say in the years 1480 and 1481, malignant epidemics appeared in the train of drought and famine in Switzerland and Germany; while putrid fever, accompanied by phrenitis, prevailed in Westphalia, Hesse, and Friesland. There never had been, in the memory of the inhabitants of these places, so many _ignes fatui_ as during this period. The harvests also failed, rendering it necessary to obtain supplies of provisions from Thuringia.