"The more frequent beats under the influence of alcohol constitute no exception to the general rule, for while the heart beats more frequently, its influence on the vasomotor nerves causes dilatation of the peripheral and systemic blood-vessels, as proved by the pulse-line written by the sphygmograph, which more than counterbalances the supposed increased action of the heart. The truth is, that under the influence of alcohol in the blood the systolic action of the heart loses in sustained force in direct proportion to its increase in frequency, until, by simply increasing the proportion of alcohol, the heart stops in diastole, as perfectly paralyzed as are the coats of the smaller vessels throughout the system. This was clearly demonstrated by the experiments of Professor Martin of Johns Hopkins University, to determine the effects of different proportions of alcohol on the action of the heart of the dog; and those of Drs. Sidney Ringer and H. Sainsbury, to determine the relative strength of different alcohols as indicated by their influence on the heart of the frog. Professor Martin states that blood containing 1/4 per cent. by volume of absolute alcohol, almost invariably diminishes, within a minute, the work done by the heart." (This estimate would equal in an adult man an amount equal to the absolute alcohol in two or three ounces of whisky or brandy.) "These investigations of Professor Martin, being directly corroborated by those of Drs. Ringer and Sainsbury, complete the series of demonstrations needed to show the actual effects of alcohol on the cardiac, as well as on the vasomotor, and also on the direct contractability of the muscular structure, when supplied with blood containing all gradations in the relative proportion of alcohol, leaving no longer any basis for the idea, popular both in and out of the profession, that alcohol in any of its forms is capable of increasing, even temporarily the force or efficiency of the heart's action."--Dr. N. S. Davis in _Influence of Alcohol On the Human System_. The following letter will be of great interest to all students of the physiological effects of alcohol:-- "CHICAGO, ILL., March 3, 1899. "To MRS. MARTHA M. ALLEN, "Syracuse, N. Y., "MADAM: Your letter asking my attention to the apparent contradiction of authorities concerning the _work_ done by the heart when influenced by alcohol was received yesterday. "The explanation is not difficult. It depends entirely on the different views of what constitutes the _work_ of the heart.