The complicated sensations in the intestinal canal, like those in the muscles, though obscure, and even unknown, as individual sensations, often constitute a general state of feeling, which is sometimes exhilarating, and sometimes depressing. The effects of opium, and of inebriating liquors, in producing exhilaration, are well known; and though much of the pleasure in these states is owing to association, as we shall afterwards explain, yet the agreeable feelings in the stomach, are the origin and cause of the joyous associations.[16] The state of feeling in the stomach in seasickness, or under the operation of an emetic, is, on the contrary, one of the most distressing within our experience; though we can neither call it a pain, nor have any more distinct conception of it, than as a state of general uneasiness. [Bain's footnote 16: The exact mode of operation of opium and alcohol is still unknown; but the part affected is probably the nervous substance and not the stomach. It can hardly be said with propriety that any part of the pleasure of these stimulants is due to association. No doubt the exhilarated tone of the mind is favourable to the flow of joyful ideas, which serve to heighten the pleasure; but that pleasure could not be arrested or subdued through the absence of any supposable associations.--_B._] The general effects of indigestion are well known. When the organs of digestion become disordered, and indigestion becomes habitual, a sense of wretchedness is the consequence; a general state of feeling composed of a multitude of minor feelings, none of {47} which individually can be made an object of attention. In the sense of wretchedness, which accompanies indigestion, and which sometimes proceeds to the dreadful state of melancholy madness, it is difficult to say, how much is sensation, and how much association. One thing is certain; that sensations which are the origin of so much misery are of high importance to us; whether they, or the associations they introduce, are the principal ingredient in the afflicting state which they contribute to create. The effects of indigestion in producing painful associations, is strikingly exemplified by the horrible dreams which it produces in sleep; not only in those whose organs are diseased; but in the most healthy state of the stomach, when it has received what, in ordinary language, is said, whether from quantity or quality, to have disagreed with it.