This is the general result, unless psoric, sycosic, syphilitic or vaccinine complications should be present. Unfortunately the abuse of cathartics excites these miasms if they exist in the organism, and at the same time prostrates the reactive powers of the organism, and enables its enemies to rise against it. The distress becomes more and more complicated; disorganizations, alterations of the fluids, disturbances of the assimilative sphere, nervous derangements from simple illusions of the sentient sphere, and occasional trembling and twitching, to spasmodic and convulsive movements, and final extinction of nervous power, marasmus of the spinal marrow or a ramollissement of the brain; these are the consequences of such miasmatic complications. In such a case Apis alone is not sufficient. We have to employ such antidotes as _Sulphur_, our most powerful anti-psoric which, unless it had been abused previously, never leaves us in the lurch in the presence of psora; _iodine_ which, under similar circumstances, becomes indispensable wherever psora and sycosis are combined; _bichromate of potash_ or _fluoric acid_, if psora, syphilis and mercurial poisoning are united; and lastly, _tartar emetic_, or again _fluoric acid_, if the vaccine poison alone, or in combination with the other poisons, occupies the foreground. This is not the place to treat of these special forms of human distress, and to individualize their treatment; I shall endeavor to do this on a more suitable occasion. I shall have to limit myself here to a superficial sketch of the treatment, adding merely that a single dose of the specific antidote will act best if given highly potentized, and that the improvement should afterwards be allowed to progress as long as a trace of it remains visible. But as soon as the improvement stops and an exacerbation sets in, which is not speedily followed by another improvement, or which seems to require our aid, we use Apis 3, one drop every day, until the improvement is again perceived, after which we wait until another exacerbation demands our interference. One dose of Apis is often insufficient; if not, from three to five doses will be found sufficient to mitigate the pains, and to advance the cure which Apis will complete in conjunction with the high potency that should not be repeated, and which is not interfered with by the Apis. What more precious boon for the physician and patient in these serious moments? It is only a physician who has instituted provings upon himself, that is capable of comprehending this harmonious blending of the two therapeutic agents. He sees the well known effects of a well known cause go and come at alternate periods. What man of common sense would be willing to repudiate such evidence? But even in a case where Sulphur and Iodine had been given to excess, and a sort of Sulphur and Iodine diathesis had been established in consequence, Apis is still the best remedy to meet this complicated derangement.