Divide into thirty pills, and give one after each discharge from the bowels, or oftener, if the urgency of the case requires it. Occasionally, however, there may be applied a large sinapism over the whole abdomen with advantage. Greenhow's aromatized brandy,[II.] the aromatic tincture of guaiacum,[III.] may sometimes be beneficially alternated with this pill. Should there be an overloaded condition of the alimentary canal, the fluid extract of rhubarb and potassa,[IV.] three parts, with saturated tincture of prickly-ash berries, one part, may be administered in table-spoonful doses every hour, and continued until the bowels are properly evacuated, after which the above astringents may be given; but where the diarrhoea is excessive, it would be imprudent to wait for catharsis, as the discharge should be checked as speedily as possible. In the second stage, when nausea, vomiting, and cramps are present, more active means should be pursued. To overcome the nausea or vomiting, the preparation of Dr. O. E. Newton, termed in the American Dispensatory compound mixture of camphor,[V.] may be used with excellent effect; it is prepared as follows: Rx. Camphor water, } Peppermint water, } [=a][=a]., f ounce j. Spearmint water, } Paregoric, f dram ij. Mix. From a tea-spoonful to a table-spoonful may be given every five or ten minutes; and in cases where this does not act sufficiently prompt, the following may be administered: Rx. Common salt, dram j. Black pepper, dram j. Vinegar, f dram v. Hot water, f ounce iv. Mix. Of this a table-spoonful may be given every ten or twenty minutes, and continued until the nausea ceases. To remove the cramps, hot bricks, or bottles of hot water, etc., should be kept applied to the feet, legs and arms, and cloths wet in water as hot as can be borne, must be applied over the abdomen and changed every few minutes; this should be perseveringly pursued until relief is obtained. Sometimes advantage will ensue from stimulant applications along the whole length of the spine. Cramps of the muscles of the limbs may be overcome by bathing with the compound cajeput mixture,[VI.] either alone or in combination with chloroform, and applying friction at the same time. This course usually checks the further progress of the disease, and the patient is saved; however, should it fail and the stage of collapse come on, in addition to the above treatment energetically pursued, the patient should be enveloped in blankets, wet with water as hot as can be borne, which should be renewed every ten or twenty minutes, and stimulants may likewise be given; the saturated tincture of prickly-ash berries will here be found beneficial, both by mouth and enema."