In the entry for March 27, 1784, there is this interesting reference: "Inoculated Cæsar, Jupiter, and Rose, at thirty francs each, ninety francs"; and if there were any doubt why Cæsar had been inoculated, a hint is immediately given under May 11: "For attention, visits, and remedies, during the smallpox (_la petite vérole_) of the mulatto Joue, sixty francs"; again we read: "June 30, inoculated a little negro _bossal_, named Joue, thirty francs." Every fresh batch of negroes landed in the colonies led to a new outbreak of this terrible scourge, and but one other disease, _la grosse vérole_,[38] was more common or more fatal among the blacks. For a long period it had been a common practice to inoculate both whites and blacks directly with the smallpox in order to secure some degree of protection against its most virulent form, but this method of fighting the devil with fire had its disadvantages. By the end of the eighteenth century opinion was about equally divided upon the advisability of continuing the measure, since induced variola or smallpox was apt to be virulent, and was often quite as infectious as when manifested in the usual and natural way. Then came Edward Jenner's grand discovery, made twelve years before this date but not announced until 1798, that vaccinia would prevent variola. Almost immediately vaccination spread like wild fire over Europe, and it has never been appreciated more fully or more highly lauded by the best representatives of the medical profession everywhere than at the present day. The most interesting references in this historic document are to "Mlle. Rabin," whose name occurs no less than seventeen times, beginning May 21, 1784, and closing with the entry for the seventeenth of August, 1785. We learn that the physician spent the nights of April 24 and 25, 1785, at the woman's bedside, and that her child was born on the twenty-sixth day of that month, probably in the morning. It will be noticed further that she had been bled previously at the arm, that she had suffered also from the erysipelas, and that later she was treated for abscesses. These frequent attentions of the physician, extending over several months, the last record being for August 17, show only too clearly that at this time Audubon's mother was in feeble health. All that is further known about her is that she died either at the close of 1785 or in 1786, when her infant son was probably less than a year old.[39] A daughter of Jean Audubon, Rosa, who was first called Muguet (in English, "Lily of the Valley"), was also born in Santo Domingo, and probably at Les Cayes, on April 29, 1787. Her mother, Catharine Bouffard, "_créole de Saint-Domingue_," who subsequently went to France, had another daughter, born also at Les Cayes, named Louise, who was living at La Rochelle in 1819.[40]