Barium: A Cause of the Loco-Weed DiseaseCrawford, Albert C. (Albert Cornelius)
Science
Barium: A Cause of the Loco-Weed Disease
Crawford, Albert C. (Albert Cornelius)
Astragalus earlei; Barium
On February 23 the temperature of this rabbit was 102.9°F. at 1.40 p.
m. She was then fed with the same amount of the extract as before. At
2.16 p.m. she lay down and became much duller; left ear fallen to side.
At 3.30 p.m. the rabbit was unable to stand. The pupil of the eye
exposed to the light was dilated. The animal died without a struggle.
The stomach contained much bloody mucus. In the dependent portion of the
stomach near the cardiac end were marked petechiæ in the walls, with
bright-red blood in the stomach itself. The heart was relaxed. The
intestines showed nothing abnormal. The dural vessels of the brain were
dilated; there was a clot on the dura over the fourth ventricle. Spinal
cord and kidneys normal, the capsules not adhering. Weight, 1,786 grams
at death.
_Experiment No. 11._--On March 1, 1906, a rabbit weighing 2,126.2 grams
was fed with a concentrated aqueous extract of 250 grams of the fresh
_Aragallus lamberti_ preserved in chloroform water. On March 5 this dose
was repeated, 37.5 c.c. of the fluid being used. March 6 the rabbit
weighed 1,956 grams; March 7, 1,913.6 grams; March 8, 1,828.5 grams;
March 9, 1,701 grams; March 12, 1,672.6 grams; March 14, 1,644.3 grams.
_Experiment No. 12._ January 19, 1906, a concentrated aqueous extract of
500 grams of the fresh _Aragallus lamberti_ preserved with chloroform
water was fed to a rabbit weighing 785 grams. The temperature at 12.10
p.m., the time of feeding, was 101.6°F. The temperature 1 hour and 43
minutes later was 94.6°F., and the animal died shortly after, showing
the same condition as occurred after feeding extracts of _Astragalus
mollissimus_.
* * * * *
FOOTNOTES:
[156] Compare Plönius, W., Beziehungen d. Geschwürs u. d.
Erosionen d. Magens z. d. funktionell. Störungen u. Krankh.
d. Darmes, Arch. f. Verdauungsk., vol. 13, pp. 180, 270,
1907, and Tixier, L., Anémies Exper. Conséc. aux Ulcér. du
Pylore, Comp. Rend. Hebd. Soc. de Biol., vol. 62, p. 1041,
1907.
=PREGNANT ANIMALS.=
_Experiment No. 13._--A large, gray, pregnant rabbit weighing 2,891.6
grams was fed on February 22, 1906, with 42 c.c. of fluid,
corresponding to the aqueous extract of 250 grams of _Astragalus
mollissimus_ collected in September and October, 1905, and preserved
with chloroform. At 4 p.m. the animal was dull, but still resisted
efforts to handle. On February 24 this animal weighed 2,778.2 grams, and
on February 26 it bore a litter of seven young rabbits. One or two of
these showed movements of the limbs, but were apparently immature. This
rabbit on March 10 weighed 2,537.3 grams; March 12, 2,438 grams; March
14, 2,508.9 grams; March 22, 2,494.7 grams.
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