On March 5 the weight was 2,296.3 grams. The animal was then given the same amount of extract. During the afternoon it passed mucus and thick pieces of feces and was dull; respiration very rapid. March 6, weight 2,282 grams; March 7, 3 p.m., animal very dull and would not eat; sat hunched up, but resisted being disturbed: weight 2,310.5 grams. March 8, weight 2,183 grams; March 9, weight 2,069.5 grams. Pupils dilated; finger could be run almost against the eye, provided the lashes were not touched, without the animal winking or paying any attention. Rabbit ate very little and had not urinated since the preceding day. Left ear had fallen to the side as if the animal were unable to support it. Weight, 1,912.8 grams. From March 9 to March 11, 67 c.c. of cloudy urine were voided. This did not clear with acetic acid. Left eye tearing. March 10, head held to right side. March 12, weight 1,786 grams. Left pupil smaller than right, neither responding to light. Rabbit very weak. March 14, weight 1,729.3 grams. Would not eat. March 16, weight 1,644.3 grams. Right pupil larger than left, neither responding to light. Diarrhea present. Breathing noisy. In sitting down she raised herself on her forelegs, evidently to take the pressure off her abdomen, which was distended. If disturbed, she would butt against the side of the cage, apparently oblivious of its presence. Knee jerks were very active, almost a clonus. Reflex from tendo Achillis active. March 17, forelegs spread out, head falling to left side. The temperature had fallen below 94°F. and would not register on the ordinary clinical thermometer. The ears twitched, the head was thrown back, the abdomen was distended, and the rabbit gritted its teeth. Died. Weight, 1,559.2 grams. Brain and spinal cord pale. Dural vessels plainly seen but not marked. Intestinal vessels congested. Stomach pale; nothing apparent macroscopically save a small pin-point ulcer.[156] Heart relaxed. Post-mortem examination otherwise negative macroscopically. _Experiment No. 10._--A mouse-colored rabbit weighing 1,927.8 grams was fed February 18, 1906, at 2.26 p.m., with a concentrated aqueous extract of 250 grams of fresh _Astragalus mollissimus_ collected in September, 1905, and preserved in chloroform water. The temperature of this rabbit was 102.6°F. The fluid given was 40 c.c. At 2.45 p.m. the rabbit urinated and at 2.57 p.m. was dull and the respiration became rapid. The animal then aborted and had three young, two of which showed some movement after birth, but were apparently premature.