Barium: A Cause of the Loco-Weed DiseaseCrawford, Albert C. (Albert Cornelius)
Science
Barium: A Cause of the Loco-Weed Disease
Crawford, Albert C. (Albert Cornelius)
Astragalus earlei; Barium
Power and Cambier, Sayre, and Kennedy had previously called attention to
the abundance of calcium in the plant, and the writer's investigations
confirm this. Pharmacologists are averse to believing calcium given per
os poisonous. The writer has, however, fed 5 grams of the acetate of
calcium in solution to a rabbit weighing 652 grams. This animal died in
two hours, with marked irritation of the stomach, the result being due
to the so-called "salt action." Much larger amounts were fed in divided
doses, but without injury. Calcium phosphate and calcium sulphate in
2-gram doses proved harmless to a rabbit weighing about 1,400 grams.
Three grams of magnesium acetate[172] were fed in solution for five
successive days to a rabbit weighing 1,417 grams, but without apparent
effect.
Strontium acetate c. p., in 2-gram doses, likewise caused no
disturbance.[173] No strontium in any amount recognizable by chemical
tests was proved in the plant. So that by a process of exclusion the
writer was forced to think of barium as the main cause of the trouble.
The writer noted that if the ashed plant was extracted with H_{2}SO_{4}
water and this extract freed from sulphuric acid with PbCO_{3} and
H_{2}S the solution proved inactive to rabbits and also that after this
extraction the acetic acid extract of the ash failed to kill. In other
words, the sulphate of our body was insoluble in water. At times in
passing H_{2}S into active solutions of the ashed plant freed from the
acetic acid by evaporation the filtrate and likewise the precipitate
were inactive. Noyes and Bray[174] have noted that if H_{2}S is passed
into certain solutions in the presence of an oxydizing agent, such as
ferric iron, H_{2}SO_{4} would be formed, which would throw any barium
out of solution.
In one blood-pressure record made with a dog (vagi nerves cut), a rise
in blood pressure (a characteristic physiological action of barium) was
seen to follow the intravenous injection of the aqueous extract of the
plant, in spite of its normal acid reaction.
Accidentally the writer found that Sprengel[175] had reported the
presence of barium in _Astragalus exscapus_, a closely allied plant.
Barium has also been found in the vegetable world by Scheele in 1788,
and later by Eckard,[176] who found it in beech, while Forchhammer[177]
proved it in birch, and Lutterkorth found it in the soil of the same
area in which Eckard worked. Dworzak[178] noted the occurrence of traces
of this element in wheat grown along the Nile, and Knop[179] found it in
the soil. Doctor Balfour, of Khartum, Egypt, informed the writer that he
knew of no cases in which this barium in wheat had produced poisoning.
Hornberger[180] found barium both in the red beech grown in Germany and
in the soil on which these trees grew. It has also been claimed that
various marine plants may take up barium from the sea.[181]
Public-domain text, read in full here on John Shaqi.
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