It is not yet decided that the JOURNAL shall be enlarged. The flattering responses already received are not sufficient in number to justify enlargement. Unless the remainder of the readers of the JOURNAL shall express themselves in favor of enlargement it will not be attempted. The editor is willing to toil without reward, but not to take up a pecuniary burden in addition. * * * * * PSYCHOMETRIC PRACTICE. Mrs. C. H. Buchanan continues to apply her skill in the description of character and disease, with general impressions as to past and future. Her numerous correspondents express much gratification and surprise at the correctness of her delineations. The fee for a personal interview is $2; for a written description $3; for a more comprehensive review and statement of life periods, with directions for the cultivation of Psychometry, $5. * * * * * MAYO'S ANAESTHETIC. The suspension of pain, under dangerous surgical operations, is the greatest triumph of Therapeutic Science in the present century. It came first by mesmeric hypnotism, which was applicable only to a few, and was restricted by the jealous hostility of the old medical profession. Then came the nitrous oxide, introduced by Dr. Wells, of Hartford, and promptly discountenanced by the enlightened (?) medical profession of Boston, and set aside for the next candidate, ether, discovered in the United States also, but far inferior to the nitrous oxide as a safe and pleasant agent. This was largely superseded by chloroform, discovered much earlier by Liebig and others, but introduced as an anaesthetic in 1847, by Prof. Simpson. This proved to be the most powerful and dangerous of all. Thus the whole policy of the medical profession was to discourage the safe, and encourage the more dangerous agents. The magnetic sleep, the most perfect of all anaesthetic agents, was expelled from the realm of college authority; ether was substituted for nitrous oxide, and chloroform preferred to ether, until frequent deaths gave warning.