been repealed; but why should these cases so generally terminate in lock-jaw[18]? The dreadful ravages occasioned formerly by the small-pox have latterly been in a great measure arrested amongst the civilised portion of the inhabitants by the general use of vaccination: accidentally conveyed to Buenos Ayres in 1805 by the owner of a cargo of slaves, it was preserved by the patriotic zeal of an enlightened priest, Dr. Segurola, who, deeply impressed with its immense importance, voluntarily devoted himself to the task of propagating it amongst his countrymen, especially the poor, whose ignorant prejudices he had often to combat, and whom he was not unfrequently obliged to bribe to submit to the operation. For sixteen years he laboured incessantly in this vocation, at the expiration of which, he had the satisfaction of finding his single exertions no longer adequate to satisfy the general demand for it. The Government then (in 1822) relieved him of his charge, and instituted a proper establishment for the express purpose of propagating vaccination gratis, not only in the city of Buenos Ayres, but throughout the republic; others were afterwards added in the several country districts, from which the lymph is now distributed to all who apply for it, and has been sent into every province of the interior. The authorities make it compulsory, as far as they can, on parents to carry their children to these establishments; and the parochial priests are charged to see that they do so. By a report published in 1829 upon this subject, it appeared that in the city alone, in the previous nine months, as many as 4160 children had been vaccinated; a large proportion to the births, which are estimated at little more than 6000 yearly. I was more than once applied to for it from Rio de Janeiro, whither it was always most readily forwarded by the Buenos Ayrean administrators. But the destruction created by the small-pox amongst the Spaniards was nothing when compared to its dreadful consequences amongst the native Indians. Whole tribes have been swept away by it: I believe, nations--whose languages have been lost. The plague is not more a frightful scourge than this disorder, when it attacks the miserable inhabitants of the pampas: they themselves believe it to be incurable, a feeling which adds to its lamentable consequences, for no sooner does it appear than their tents are raised, and the whole tribe takes to flight, abandoning the unfortunate sufferers to the certainty of perishing of hunger and thirst, if the virulence of the disorder itself does not first carry them off. An opportunity, however, offered during the time I was at Buenos Ayres of making known to these poor people, also, the effects of vaccination, under circumstances which it is to be hoped may eventually lead to its diffusion amongst them, as well as their more civilised neighbours.