The two most familiar pharmaceutical allusions in Shakespeare’s writings are the apothecary and his shop in “Romeo and Juliet” (Act V., Sc. 1), and the juice of cursed hebenon which Hamlet’s uncle poured into the ear of his father (“Hamlet,” Act I., Sc. 5). Some remarks on both these noted allusions are given separately. The medical knowledge of Shakespeare has been discussed by several eminent doctors, notably by Dr. J. C. Bucknill, of Exeter, who published a very interesting work under that title in 1860, in which the writer almost went so far as to hint at the possibility that the great dramatist must have had some training in the medical science of the day before he took to the theatre business. A similar suggestion was made by Lord Campbell in regard to the poet’s legal knowledge. Great interest in drugs and poisons was taken by the people generally in Queen Elizabeth’s reign, and the medical controversies of the period filled a good many books. It is certain that Shakespeare at least skimmed a good many of these. “Galen and Paracelsus” are mentioned in “All’s Well that Ends Well” (Act II., Sc. 3). In “Coriolanus” (Act II., Sc. 1) Menenius says of a letter from Coriolanus that it gives him an estate of seven years’ health, adding “the most sovereign prescription in Galen is but empiricutick, and,” compared with this letter, “of no better report than a horse-drench.” Apothecaries are mentioned in “Henry VI” (Part II., Act III., Sc. 3), when Cardinal Beaufort, delirious on his deathbed, cries, “Bid the apothecary bring the strong poison that I bought of him.” Also in “Pericles” (Act III., Sc. 2), the amateur physician Cerimon, a Lord of Ephesus, who had studied medicine, and “by turning o’er authorities” had made himself familiar with “the blest infusions that dwell in vegetives, in metals, stones,” gives a prescription to his servant, saying, “Give this to the ’pothecary, and tell me how it works.” Apothecaries’ weights are used as metaphors in “All’s Well that Ends Well” (Act II., Sc. 3) when Lafeu, who has given Parolles “most egregious indignity,” which the latter says he has not deserved, replies “Yes, good faith, every dram of it; and I will not bate thee a scruple,” and by Falstaff, who, in his interview with the Chief Justice, refers rather enigmatically to drams and scruples. Falstaff again, in “Merry Wives of Windsor,” is responsible for the simile of those who “smell like Bucklersbury in simple time.” The Dr. Caius in the same play, with his “by gar” and comical English, is assumed by some interpreters to have been a burlesque on Sir Theodore Mayerne, but except that Mayerne was French and certainly spoke English with a foreign accent, there is no reason for associating him with the character. Mayerne never acquired English. In one of his later letters he writes of Lady Cherosbury, for Shrewsbury. There was a very famous Dr. Caius, who had been physician to Queen Elizabeth, who founded