Historical and botanical account of the plant and its uses; the result of a series of experiments on its use was most unsatisfactory, although the drug was given in every variety of ways, under all circumstances, and at all hours of the day.—L. i./76,631,664. Two ascents of Ben Voirlich, under the influence of, respectively, 60 and 90 grains, done with ease by Sir Robert Christison. By the use of Coca, hunger and thirst are suspended, but eventually appetite and digestion are unaffected; the mental faculties are not affected after great bodily fatigue, except by freeing them from dulness and drowsiness.—B.M.J. i./76,527; P.J. 1876,883. Twelve athletes, during a game, chewed, without lime or ashes, from 60 to 90 grains; at first in some, dryness was felt, and relieved by washing the mouth; then followed a feeling of invigoration, so that fatigue was wholly or in great part resisted; the pulse increased in frequency, and perspiration augmented. Save exhilaration of spirits, no mental effects were noticed or disagreeable effects realised.—P.J. 1877,221. A party climbing Mont Blanc, each chewing 80 grains of Coca during ten hours, were much relieved from thirst by its use. They drank no water, tea, or coffee, and but a limited amount of wine, yet Coca enabled them to make the trip with comparative comfort.—M.T.G. ii./82,165. It enables a greater amount of fatigue to be borne with less nourishment, and lessens the difficulty of respiration in ascending mountain sides. Tea made from it has much the taste of green tea, and is much more effectual in keeping people awake.—Markham’s Peruvian Bark, p. 152. In France, Bouchardat states it has rendered most valuable therapeutic service, almost equal to cinchona bark. It is a stimulant to the nervous and muscular systems, and ranks with tea and coffee; it prevents the rapid waste of tissue, and enables the consumer to go a long time without food.—B.M.J. i./76,486. Use in walking feats.—B.M.J. i./76,335,361,387,518,519,750,752. The leaves are neither nutritive nor tonic; it is in their anæsthetic properties, developed by chewing the leaves with lime or plant ash, the Indian finds the numbing effect on the mucous membrane of the stomach that he seeks.—P.J. 1885,266. Fluid extract of Coca relieved hæmorrhage from bowel when given internally.—Pr. xxxv.401. And gives great relief in gastralgia.—M.P.C. ii./87,479. Report on the Coca alkaloids.—B.M.J. i./89,1043,1108,1158. CHAPTER XIV. COCAINE AND ITS SALTS. =COCAINA=, Cocaine. _Dose._—¹⁄₂₀ to 1 grain, in a pill or tablet.