"The protoplasm of the botanist, and the contractile substance and sarcode of the zoologist, must be, if not identical, yet in a high degree analogous substances. Hence, from this point of view, the difference between animals and plants consists in this; that, in the latter, the contractile substance, as a primordial utricle, is enclosed within an inert cellulose membrane, which permits it only to exhibit an internal motion, expressed by the phenomena of rotation and circulation, while, in the former, it is not so enclosed. The protoplasm in the form of the primordial utricle is, as it were, the animal element in the plant, but which is imprisoned, and only becomes free in the animal; _or_, to strip off the metaphor which obscures simple thought, the energy of organic vitality which is manifested in movement is especially exhibited by a nitrogenous contractile substance, which in plants is limited and fettered by an inert membrane, in animals not so."[1] [Footnote 1: Cohn, "Ueber Protococcus pluvialis," in the "Nova Acta" for 1850.] In 1868, thinking that an untechnical statement of the views current among the leaders of biological science might be interesting to the general public, I gave a lecture embodying them in Edinburgh. Those who have not made the mistake of attempting to approach biology, either by the high _à priori_ road of mere philosophical speculation, or by the mere low _à posteriori_ lane offered by the tube of a microscope, but have taken the trouble to become acquainted with well-ascertained facts and with their history, will not need to be told that in what I had to say "as regards protoplasm" in my lecture "On the Physical Basis of Life," there was nothing new; and, as I hope, nothing that the present state of knowledge does not justify us in believing to be true. Under these circumstances, my surprise may be imagined, when I found, that the mere statement of facts and of views, long familiar to me as part of the common scientific property of continental workers, raised a sort of storm in this country, not only by exciting the wrath of unscientific persons whose pet prejudices they seemed to touch, but by giving rise to quite superfluous explosions on the part of some who should have been better informed.