In 1757 Dr. Cullen first undertook to give clinical lectures in the infirmary, and in this work his especial talents shone. He had now had sufficient experience of practice, with the best knowledge of chemistry and materia medica that the time afforded; and his skill in observation and graphic description of disease, added to his zeal for imparting knowledge, soon made his clinical lectures renowned. In these lectures, for eighteen years most carefully prepared, the first real model of what is now so familiar to medical students as a clinical lecture was afforded. His candour may be judged from the following expressions: “In these lectures, however, I hazard my credit for your instruction, my first views, my conjectures, my projects, my trials, in short, my thoughts, which I may correct and if necessary change; and whenever you yourselves shall be above mistakes, or can find anybody else who is, I shall allow you to rate me as a very inferior person. In the meantime I think I am no more liable to mistakes than my neighbours, and therefore I shall go on in telling you of them when they occur.” Promoted by such candour, Cullen’s reputation rapidly grew. His lectures were remarkable for simplicity, ingenuity, and comprehensiveness of view, with copiousness of illustration. He taught his students to observe the course of nature in diseases, to distinguish between essential and accidental symptoms, and to carefully discriminate the influence of remedies from the curative operations of nature. “There is nothing,” he said, “I desire so much as that every disease we treat here should be a matter of experience to you, so you must not be surprised that I use only one remedy when I might employ two or three; for in using a multiplicity of remedies, when a cure does succeed, it is not easy to perceive which is most effectual.” Again, he says, “Every wise physician is a dogmatist, but a dogmatical physician is one of the most absurd animals that lives. We say he is a dogmatist in physic who employs his reason, and, from some acquaintance with the nature of the human body, thinks he can throw some light upon diseases and ascertain the proper methods of cure; and I have known none who were not dogmatists except those who seemed to be incapable of reasoning, or who were too lazy for it. On the other hand, I call him a dogmatical physician who is very ready to assume opinions, to be prejudiced in favour of them, and to retain and assert very tenaciously, and with too much confidence, the opinions or prejudices which he has already taken up in common life, or in the study of the sciences.” He sought to build up rational views of medicine, indeed, on the basis of fact and experiment. In giving his clinical lectures he was at great pains to choose diseases of the most common types, as most useful to the students. He adhered to great simplicity of prescriptions, compared with the complex and barbarous nostrums