drug administered by the mouth or subcutaneously and the same administered by electrolysis. Thus a solution of cocaine injected subcutaneously produces quite different effects to that introduced by electrolysis. By the latter method it produces anaesthesia but does not diffuse, and the anaesthesia remains strictly limited to the surface covered by the electrode. It would appear that the ion is never introduced into the general circulation but into the cell plasma. In the technical working of medical electrolysis the most minute precautions are required. The solution of the drug must be made with as pure water as possible, recently distilled. The spongy substance forming the electrode must be free from any trace of electrolytic substances. Hence all materials used must be washed in distilled water. Absorbent cotton answers all requirements and is easily procured. The area of introduction can be exactly circumscribed by cutting a hole in a sheet of adhesive plaster which is applied to the skin and on which the electrolytic electrodes are pressed. The great advantage of electrolytic methods is that it enables general treatment to be replaced by a strictly local treatment, and the cells can be saturated exactly to the degree and depth required. Strong antiseptics and materials that coagulate albumen cannot be introduced locally by ordinary methods, as the skin is impermeable to them, but by electrolysis they can be introduced to the exact depth required. The local effects of the ions depend on the dosage; thus a feeble dose of the ions of zinc stimulates the growth of hair, but a stronger dose produces the death of the tissue. Naturally the different ions produce different effects. Thus the ions of the alkalis and magnesium are caustic, those of the alkaline earthy metals produce actual mortification of the tissue and so on. According to the ion chosen the effect may be caustic in various degrees, antiseptic, coagulating, producing vascular or nervous changes, &c., &c. And again electrolysis can also be used for extracting from the body such ions as are injurious, as uric and oxalic acid from a patient suffering from gout.