Another effect of an electric current is electrolysis, and the phenomena
of electrolytic conduction involve not merely the ionization of the
compounds, but also the setting in motion of the ions towards their
respective poles. Solutions which conduct electric currents are called
electrolytes, and in the case of the human body the electrolyte is the
whole mass of the saline constituents in solution throughout the body.
When a current is passed through an electrolyte, dissociation into ions
takes place, the ions which are freed round the anode being called
anions and those which are freed round the kathode being called kations.
The anions carry negative charges and are consequently attracted by the
positive electricity of the anode. The kations carry positive charges,
hence they are repelled by the anode and attracted by the kathode. But a
certain number of molecules do not dissociate, and hence in an
electrolytic solution there are neutral molecules, anions and kations.
The chemical actions, and thus the antiseptic, remedial or toxic effects
of electrolytes, are due to the actions of their ions. The phosphides
and phosphates may be taken as examples. Some are extremely toxic, while
others are quite harmless. But it is to the phosphorus ion that the
toxic or therapeutic effect is due. In the phosphates the phosphorus is
part of a complex ion possessing quite different properties to those of
the phosphorus ion of the phosphides. The strikingly different effects
of the sulphates and sulphides are due to similar conditions, as also of
many other compounds. There are certain solvents, as alcohol,
chloroform, glycerin and vaseline which do not dissociate electrolytes,
and consequently the latter become inert when mixed with these solvents.
These solutions do not conduct electricity, and hence ionic effects are
extremely slow. A vaseline ointment containing 5% of phenol makes a good
dressing for an ulcer of the leg, and produces no irritant effect, but a
5% aqueous solution may be both caustic and toxic. Since the toxic or
therapeutic action of a solution is due to its ions, the action must be
proportional to the number of ions in a given volume, that is, the
action of an electrolyte depends on the degree of dissociation. Thus a
strong acid is one that is much dissociated, a weak acid one that has
undergone but little dissociation and so on. In 1896-1897 it was shown
that the bactericidal action of salts varies with their degree of
dissociation and therefore depends on the concentration of the active
ions. In the medical application of these facts it must be remembered
that when an ion is introduced into the body by electrolysis, it is
probably forced into the actual cellular constituents of the body,
whereas the drug administered by one of the usual methods though
circulating in the blood may perhaps never gain access to the cell
itself. Hence the different effects that have been recorded between a
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