That which we may distinguish as _transverse integration_, is well illustrated among the _Annulosa_ in the development of the nervous system. Leaving out those simple forms which do not present distinct ganglia, it is to be observed that the lower annulose animals, in common with the larvæ of the higher, are severally characterized by a double chain of ganglia running from end to end of the body; while in the more advanced annulose animals this double chain becomes a single chain. Mr. Newport has described the course of this concentration in insects; and by Rathke it has been traced in crustaceans. In the early stages of the _Astacus fluviatilis_, or common cray-fish, there is a pair of separate ganglia to each ring. Of the fourteen pairs belonging to the head and thorax, the three pairs in advance of the mouth consolidate into one mass to form the brain, or cephalic ganglion. Meanwhile out of the remainder, the first six pairs severally unite in the median line, while the rest remain more or less separate. Of these six double ganglia thus formed, the anterior four coalesce into one mass; the remaining two coalesce into another mass; and then these two masses coalesce into one. Here we see longitudinal and transverse integration going on simultaneously; and in the highest crustaceans they are both carried still further. The _Vertebrata_ exhibit this transverse integration in the development of the generative system. The lowest of the mammalia--the _Monotremata_--in common with birds, have oviducts which towards their lower extremities are dilated into cavities severally performing in an imperfect way the function of a uterus. "In the _Marsupialia_, there is a closer approximation of the two lateral sets of organs on the median line; for the oviducts converge towards one another and meet (without coalescing) on the median line; so that their uterine dilatations are in contact with each other, forming a true 'double uterus.' ... As we ascend the series of 'placental' mammals, we find the lateral coalescence becoming gradually more and more complete.... In many of the _Rodentia_, the uterus still remains completely divided into two lateral halves; whilst in others, these coalesce at their lower portion, forming a rudiment of the true 'body' of the uterus in the Human subject. This part increases at the expense of the lateral 'cornua' in the higher Herbivora and Carnivora; but even in the lower Quadrumana, the uterus is somewhat cleft at its summit."[6] And this process of transverse integration, which is still more striking when observed in its details, is accompanied by parallel though less important changes in the opposite sex. Once more; in the increasing commissural connexion of the cerebral hemispheres, which, though separate in the lower vertebrata, become gradually more united in the higher, we have another instance. And further ones of a different order, but of like general implication, are supplied by the vascular system.