The report from the Hospital for Sick Children, Paris, is contained in
a memoir, _Sérum-Thérapie de la Diphtérie_, the joint work of MM.
Roux, Martin, and Chaillon (_Annales de l'Institut Pasteur_, September
1894). It gives the results of the serum-treatment during February to
July 1894. The cases were not selected: the antitoxin was given in
every case that was proved, by bacteriological examination, to be
diphtheria--with the exception of 20 cases where the children were
just dying when they were brought to the hospital. No change was made
either in the general treatment or in the local applications to the
throat; these were the same that had been used in former years: _le
sérum est le seul élément nouveau introduit_.
In 1890-1893, before the serum-treatment, 3971 children were admitted
to the diphtheria wards, and 2029 of them died. The percentage of
these deaths was--
In 1890 55.88 }
" 1891 52.45 } Average = 51.71.
" 1892 47.64 }
" 1893 48.47 }
The serum was used from 1st February to 24th July 1894. During this
period 448 children were admitted, of whom 109 died = 24.5.
During the same period (February to June) the Trousseau Hospital,
where the serum was not used, had 520 cases, with 316 deaths = 60.0.
The cases at the Hospital for Sick Children must be divided into those
that required tracheotomy and those that did not require it:--
MORTALITY AMONG CASES NOT REQUIRING TRACHEOTOMY.
In 1890 47.30 }
" 1891 46.64 } Average = 33.94.
" 1892 38.8 }
" 1893 32.02 }
During the serum-period, the mortality of these cases was 12.0. At the
Trousseau Hospital, without the serum, the mortality of these cases
during the same period was 32.0.
MORTALITY AMONG CASES REQUIRING TRACHEOTOMY.
In 1890 76.35 }
" 1891 68.36 } Average = 73.49.
" 1892 74.6 }
" 1893 73.45 }
During the serum-period, the mortality of these cases was 49.0. At the
Trousseau Hospital, without the serum, the mortality of these cases
during the same period was 86.0.
Setting aside, out of the 448 children, those cases of "membranous
sore throat" or "pseudo-diphtheria," in which the Klebs-Loeffler
bacillus was not found, there remain 320 cases where it was found. Of
these 320 children, 20 were just dying on admission, and did not
receive the serum. Of the 300 who received it, 78 died = 26.0. Before
the serum-period, the mortality of these cases at the same hospital
was about 50.0. The complications of diphtheria, such as paralysis,
were much less frequent during the serum-period than they had been
before it.
II
Report of the American Pædiatric Society's Collective Investigation
into the use of Antitoxin in the treatment of diphtheria in private
practice. (Eighth Annual Meeting, Montreal, May 1896.) From the _New
York Medical Record_, 4th July 1896.
Public-domain text, read in full here on John Shaqi.
Reviews
Reviews
No reviews yet
Be the first to share your thoughts on this work.
Elsewhere in the archive
Join the Discussion
Join the discussion
Sign in to leave a comment or review.
Sign InorCreate an account