"No definite conclusion can be drawn, for the reasons stated in the body of the report, as to the advantage of administering the whole of the antitoxin within forty-eight hours of the first injection, or continuing it for a longer period; but evidence is afforded of the importance of its administration as early as possible in the course of the disease; the percentage mortality in cases injected on the first and second days of the disease being 10.7, as compared with 25.5 for those first receiving the injection on the fifth or some subsequent day. "No conclusion can be drawn, from the cases reported on, as to the amount of antitoxin which should be used to produce the best effects; but they show that the administration of very large doses is followed by no pronounced ill effects. "The injection of antitoxin is responsible for the production of rashes, joint-pains, and possibly for the occurrence of late pyrexia. In 34.7 per cent. the injections were followed by rashes. Some amount of fever accompanied the rash in 60 per cent. In only 9.4 per cent. of those in whom rashes were observed did death ensue. "Joint-pains were observed in 40, or 6.3 per cent. of the whole number, and all but five of them had a rash as well. "In 26, or 65 per cent. of the joint-pains, some rise of temperature accompanied the pain. A rise of temperature during convalescence, accompanied by either rash or joint-pain, occurred in 27, or 4.2 per cent. of the whole number. "No connection could be traced between the amount of antitoxin administered and the occurrence of rashes or late pyrexia, but the pain in and about the joints appears to have a relationship to the amount of antitoxin used. "The results of the Committee's investigation tend to show that by the use of antitoxin-- 1. The general mortality is reduced by one-third. 2. The mortality in tracheotomy falls by one-half. 3. Extension of membrane to the larynx very rarely occurs after the administration of antitoxin. 4. The duration of life in the fatal cases is decidedly prolonged. 5. The number of fatal cases is less when antitoxin is used early in the illness than in those which do not receive it until a later period. 6. The frequency of the occurrence of paralysis is not diminished, but the percentage of recoveries in cases with paralysis is slightly increased.[22] 7. Rashes are produced in about one-third of the cases, and are attributable to the antitoxin. 8. Pain, and occasionally swelling about the joints, are produced in a number of cases. 9. Even when used in large doses, no serious ill effects have followed the injection of antitoxin."