Accordingly, points of _unlikeness_ are as important as points of _likeness_ among the cases examined. _Comparison_, without _contrast_, does not amount to anything logically. In the degree in which other cases observed or remembered merely duplicate the case in question, we are no better off for purposes of inference than if we had permitted our single original fact to dictate a conclusion. In the case of the various samples of grain, it is the fact that the samples are unlike, at least in the part of the carload from which they are taken, that is important. Were it not for this unlikeness, their likeness in quality would be of no avail in assisting inference.[16] If we are endeavoring to get a child to regulate his conclusions about the germination of a seed by taking into account a number of instances, very little is gained if the conditions in all these instances closely approximate one another. But if one seed is placed in pure sand, another in loam, and another on blotting-paper, and if in each case there are two conditions, one with and another without moisture, the unlike factors tend to throw into relief the factors that are significant (or "essential") for reaching a conclusion. Unless, in short, the observer takes care to have the differences in the observed cases as extreme as conditions allow, and unless he notes unlikenesses as carefully as likenesses, he has no way of determining the evidential force of the data that confront him. [16] In terms of the phrases used in logical treatises, the so-called "methods of agreement" (comparison) and "difference" (contrast) must accompany each other or constitute a "joint method" in order to be of logical use. [Sidenote: Importance of exceptions and contrary cases] Another way of bringing out this importance of unlikeness is the emphasis put by the scientist upon _negative_ cases--upon instances which it would seem ought to fall into line but which as matter of fact do not. Anomalies, exceptions, things which agree in most respects but disagree in some crucial point, are so important that many of the devices of scientific technique are designed purely to detect, record, and impress upon memory contrasting cases. Darwin remarked that so easy is it to pass over cases that oppose a favorite generalization, that he had made it a habit not merely to hunt for contrary instances, but also to write down any exception he noted or thought of--as otherwise it was almost sure to be forgotten. § 3. _Experimental Variation of Conditions_ [Sidenote: Experiment the typical method of introducing contrast factors]