Irritability : $b a physiological analysis of the general effect of stimuli in living substanceVerworn, Max
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Irritability : $b a physiological analysis of the general effect of stimuli in living substance
Verworn, Max
Irritability
Finally, the
recent investigations of _Vészi_[32] with strychnine poisoned ganglia
cells of the posterior horns of the spinal cord, have made it appear
probable that “the all or none law” can be applied likewise to the
individual ganglion cell. He draws this conclusion not only from the
fact that all reflex contractions of a muscle of a strychninized frog
are maximal, whether they are produced by weak or strong stimuli, but
also especially because of the loss in the strychninized spinal cord
of the capacity of the summation of irritability. The normal spinal
cord does not reflexly respond at all to weak single stimuli, but
responds to equally weak faradic stimulation very readily. Therefore,
the threshold lies very high for the individual induction shock and
very low for faradic shocks. But these differences are equalized in the
strychninized frog. This seems intelligible, when we assume that the
strychninized cell responds to every stimulus, to which it responds
at all, to the maximal extent which is permitted at that moment by
its stored up energy, otherwise the excitation would necessarily be
summated by faradic stimulation.
[26] _Bowditch_: “Ueber die Eigentümlichkeiten der Reizbarkeit,
welche die Muskelfasern des Herzens zeigen.” In Arbeiten aus der
physiologischen Anstalt zu Leipzig VI. Jahrgang 1872.
[27] _Kronecker_: “Das characteristische Merkmal der
Herzmuskelbewegung.” In Beiträge zur Anat. und Physiol. Als. Festgabe
Carl Ludwig gewidmet von seinen Schülern. Leipzig 1874.
[28] _McWilliams_: “On the rhythm of the mammalian heart.” Journal of
Physiology, Vol. IX, 1888.
[29] _Gotch_: “The submaximal electrical response of nerve to a
single stimulus.” Journal of Physiology, Vol. XXVIII, 1902.
[30] _Keith Lucas_: “On the graduation of activity in a skeletal
muscle fibre.” Journal of Physiology, Vol. XXXIII, 1905–06.
[31] _Keith Lucas_: “The all or none contraction of skeletal muscle
fibre.” Journal of Physiology, Vol. XXXVIII, 1909.
[32] _Vészi_: “Zur Frage des Alles oder Nichts-Gesetzes beim
Strychninfrosch.” Zeitschrift für allgemeine Physiologie Bd. XII,
1911.
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