On this occasion it was observed, that the patient's memory was not so good as formerly, and that there was a certain amount of mental as well as bodily languor. His hearing was likewise sluggish, the words having occasionally to be repeated before they made an impression on the cerebral organ. This, no doubt, arose from the poisonous effects of the bile circulating in his blood. It may be here mentioned, that in cases of jaundice from suppression we seldom or never meet with those extreme symptoms of cerebral disturbance which are so common in cases of jaundice from obstruction. I believe the reason of this difference in the two forms of jaundice arises from the circumstance that the really poisonous parts of the bile are the biliary acids, and that they, like urea, are powerful narcotic poisons. The results of the experiments on artificial jaundice (page 95) led me to this conclusion. As neither the symptoms nor physical signs threw any additional light on this interesting case, {78} it was determined once more to bring chemistry and the microscope to bear upon it, with the view of, if possible, extending the information these methods of investigation had already yielded. Accordingly, a specimen of the urine was again obtained for analysis, and it yielded the following results:-- 24 HOURS' URINE. Quantity, (43 oz.) . . . . 1333 c.c. Specific gravity . . . . . 1016. Reaction . . . . . . . . . Acid. Urea . . . . . . . . . . . 23·994 grammes. Uric acid . . . . . . . . 0·266 " Bile pigment . . . . . . . Abundant. Bile acids . . . . . . . . Small quantity. Sugar . . . . . . . . . . A little. Solids (total) . . 41·989 Organic matter . . . . . . 31·992 Inorganic . . . . . . . . 9·997