At this period the leprosy had already begun to assume a venereal type of marked character, and many prostitutes suffered from attacks. As we all are aware, Jean Manardi, an Italian doctor, has fully expressed his opinion on this subject. In a letter addressed to a friend, Michel Santana, one of the first specialists who treated pox, Manardi remarks: “This disease has attacked Valencia, in Spain, being spread broadcast by a famous courtesan, who, for the price of fifty crowns, accorded her favors to a nobleman suffering from leprosy. This woman having been tainted, in her turn contaminated all the young men who called on her, so that more than four hundred were affected in a brief space of time. Some of these, having followed the fortunes of King Charles into Italy, carried and spread this cruel malady in their track.” Another Italian physician, Andre Mathiole, likewise shows the identity of leprosy with syphilis,—in the following terms: “Some authors have written that the French have taken this disease from impure commerce with leprous women while traversing the mountains of Italy.”[30] We could easily multiply such citations to complete the facts observed by Fernel and Ambroise Pare in France, and also by many Italian physicians, from whence it would be easy to understand why Manardi came to the following conclusion: “Those who have connection with a woman who has had recent _amours_ with a leper, a courtesan in whose womb the seeds of disease may linger, sometimes contract leprosy and at other times suffer from other maladies of a more or less serious nature, according to their predispositions.” This modification from _measles_ (the disease from corrupt pork diet) into leprosy of the venereal type is made progressively through the intermediary of the ordinary agencies of prostitution,—bawds and libertines,—who for a very long period eluded the wise laws ordained by sanitary police for the restriction of lepers. In 1543, the affection was so wide-spread as to be beyond sanitary control, and the edict of Francois I., re establishing leper hospitals, amounted to nothing. There were too many poxed people. The Hospital of Lourcine, which was specially devoted to these cases at Paris contained 600 patients in 1540, and in the wards of Trinity Hospital and the Hotel Dieu there were many more. It was the same in the Provinces, notably at Tolouse, which had the merit of creating the first venereal hospital ever instituted, under the Gascon name of “_Houspital das rognousez de la rougno de Naples_.” Finally, fifty years later, in 1606, for want of lepers, the leper asylums were officially closed. Henry IV., in a proclamation, gave those remaining “to poor gentlemen and crippled soldiers.”