We must insist on the fact that the thyroid and the pituitary body are antagonistic; the thyroid diminishes, the pituitary augments, blood-pressure. The same antagonistic relations exist also between the thyroid and adrenals, as already mentioned. The adrenals play an important rôle also in the defense of the organism against infections and intoxications, as we will point out in a separate chapter. We will only recall here that already (1903) Sajous[79] has insisted upon the important rôle of the adrenals in the production of fever. Footnote 79: “Internal Secretions,” vol. i, p. 33. The co-operation of the sexual glands in protecting the body from infectious disease can be shown by the fact found by Professor Cornil,[80] of Paris, that in infectious diseases, such, for instance, as typhoid fever, there is frequently sudden menstruation, with abundant metrorrhagia, the autopsy often showing hypertrophy of the corpus luteum. Footnote 80: Quoted after Loisel. Metschnikoff[81] and Matschinski found, after injections of the bacilli of tetanus, or of diphtheria, the greatest number of them in the ovaries, or in the testicles, of the animals. It is also of great interest that Lingard[82] found that the subcutaneous injection of testicular extracts into cattle induces a resistance to infection from bovine plague, against which other cattle can also be rendered immune through the serum of the treated animals—which seems very important to us. Brown-Sequard and d’Arsonval employed testicular extracts with good result in tuberculosis, and Uspenski in cases of Asiatic cholera.[83] Footnote 81: Metschnikoff: Annales de l’institut Pasteur, 1900. Footnote 82: Lingard: Centralblatt für Bacteriologie, vol. xxxviii, Nu. 2, p. 246. Footnote 83: Comptes Rendus de la Société de Biologie de Paris, Nov. 5, 1896. In the chapter on the treatment of old age by organic extracts, we submit evidence showing that infectious diseases have been treated successfully by several authors by these extracts. Many others have also shown that spermin, prepared by Professor Poehl from the testicles of various animals, has also a marked effect against different infectious diseases, sometimes even in cases of desperate septicæmia. It has been shown by Professor Loewy and Dr. Richter, that after giving spermin there is at first a great diminution of the leucocytes in consequence of leucolysis, which is soon followed by hyperleucocytosis, and at the same time there was considerable increase of alkalinity in the blood.[84] Footnote 84: Richter: Organotherapie.