On Digestive Proteolysis: Being the Cartwright Lectures for 1894Chittenden, R. H. (Russell Henry)
Science
On Digestive Proteolysis: Being the Cartwright Lectures for 1894
Chittenden, R. H. (Russell Henry)
Digestion; Digestive enzymes; Enzymes
It is of course to be understood that diffusion experiments made with
dead parchment membranes cannot necessarily be expected to throw much
light upon the rate of absorption of these bodies through the living
membranes of the stomach and intestine, where, as Waymouth Reid[143]
has well said, we have to deal with an absorptive force dependent, no
doubt, upon protoplasmic activity, and comparable, in part at least,
to the excretive force of a gland-cell. Furthermore, in considering
absorption as it occurs in the living stomach, we must necessarily
give due weight to the selective power of the epithelial cells,
a power which may be far more potent even than we suppose. Hence,
without attempting at this point to draw any broad deductions from our
experiments we may simply lay stress upon the facts themselves, viz.,
that the primary products of pepsin-proteolysis are diffusible, and,
like true peptones, are capable of passing through animal and vegetable
membranes, although to a less extent. We may further emphasize the
fact that experiments of this character on diffusibility can, at the
most, only indicate general tendencies, since every variation in the
attendant conditions will exercise some influence upon the final result.
[143] Osmosis Experiments with Living and Dead Membranes. Journal of
Physiol., vol. xi, p. 312.
With reference to the bearing digestive experiments made in dialyzer
tubes have upon the natural process as carried on in the living
stomach, we must necessarily grant that the conditions approximate
only in the crudest way to those existent in the alimentary tract.
At the same time, if complete peptonization is characteristic of
pepsin-proteolysis in the stomach, and failure to obtain such results
in an artificial digestion is due to lack of withdrawal of the
diffusible products formed, then certainly the experiments carried on
in dialyzer tubes, with abundant opportunity for diffusion, and with a
large excess of free hydrochloric acid, should show some indications of
increased peptone-formation. But none were obtained.
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