These circumstances, in the living vessels, are when the blood becomes separated into small quantities, and when it moves slowly along the capillaries. The blood will then coagulate in circumscribed patches,[38] as illustrated in the first characteristic marks of secondary disease which have already been mentioned as occurring in the lungs, the liver, the spleen, and the skin. The accompanying plate is taken from the lung of a donkey in which purulent fluid had been made to circulate with the blood. The stagnation of the blood, when the pus was first introduced, was mechanically prevented, and the livid spots produced by its subsequent coagulation in the capillaries of the lungs has been very faithfully represented. (See Experiment No. VI.) [38] The term ecchymosis does not appear appropriate to the discoloured condition of parts observed in the commencement of this disease; the blood is not at first extravasated from the vessels, but coagulated in them. "Besides the disposition for coagulation," observes Mr. Hunter, "the blood has, under certain circumstances, a disposition for the separation of the red globules, and probably of all its parts; for I have reason to believe, that a disposition for a separation of the red part and coagulation, are not the same thing, but arise from two different principles. This is always observable in bleeding; for if we tie up an arm and do not bleed immediately, the first blood that flows from the orifice, or that which has stagnated for some time in the veins, will soonest separate into its three constituent parts: this circumstance exposes more of the coagulating lymph at the top, which is supposed by the ignorant to indicate more inflammation, while the next quantity taken suspends its red parts in the lymph, and gives the idea that the first small quantity had been of such service at the time of its flowing, as to have altered for the better the whole mass of blood. Best, therefore, maybe regarded as one of the immediate causes of the separation." _Hunter_, p. 29.