CASE II. Richard Mason had a small cancerous tumour removed from the lower lip. The operation was performed in the usual way, and the wound appeared to heal by the first intention; a small abscess, however, followed by some ulceration, subsequently appeared in the neighbourhood of the cicatrix. Nine days after the operation, he complained of sore throat and general uneasiness, and three days afterwards he was seized with rigors, followed by cold perspiration and coma. _Post-mortem appearances._ A small deposit of matter was found, situated beneath the fascia of the left thigh. The synovial membrane of the left knee was highly inflamed, and contained a large quantity of pus. On the right side, the skin of the whole inferior extremity presented a dark livid appearance, with the exception of that situated upon the fore part of the thigh. The same dark colour was observed in the muscles of the limb, which were infiltrated with blood and serum. The arteries and veins were discoloured, but in other respects presented nothing remarkable. It was ascertained, that, two years previously, this patient had suffered from diabetes; and upon examining the urine found in the bladder, it was found to contain sugar. CASE III. Jane Thornton, æt. 32, came under treatment on the 22nd of March. A week previously, her right ancle had become red and painful, and inflammation subsequently extended up the inner side of the leg. When first seen, she was evidently much out of health, although no one organ could be said to be particularly affected. On the 28th of March, she was attacked with severe rigors, and experienced pains in different parts of her limbs: the rigors were repeated for several days in succession. The inflammation of the leg now entirely disappeared, and she complained of pain in the right knee, which was slightly swollen. On the 31st, her bowels became much relaxed; there was great general depression, and much nervous agitation. Both knees were swollen. The general symptoms now became somewhat relieved; but on the 4th April, she was attacked with vomiting, which recurred frequently during the day, and was accompanied with great depression, and severe pain in the epigastrium. On the 5th, the sickness continued, apparently quite uninfluenced by any remedies. She passed considerable quantities of blood by stool: her countenance presented a dusky yellow hue: the pulse was excited, without power, and the sense of depression was greatly increased. On the 7th, the vomiting still continued, and she still passed blood by stool. Some spots of a dark purple colour now made their appearance upon her face. The hands both became slightly swollen; and upon the right one, some small, dark, livid spots, similar to those upon the face, made their appearance. She was much troubled with hiccough. On the 9th, the countenance was very anxious, the complexion more sallow: some more livid spots appeared upon the face and cheeks.