Gonorrhœa extending to the bladder, and producing absolutely a clap of the bladder. If the inflammation is not subdued, or does not subside, probably some permanent mischief ensues; at all events, the inflammation extends, and involves other coats than the interior. Accordingly, we have inflammation of the muscular coat, the nervous coat, and, lastly, the peritoneal coat. These terminations, severally, have certain symptoms, and certain names. There are others, and among them may be named colds, local injuries, hæmorrhoids, excess in drinking particular fluids, sensual indulgences, diseased condition of the kidneys, or long retention or vitiated states of the urine, nervousness, and, lastly, the formation of stone in the bladder. The most common form of bladder ailment is irritability, which is a milder term for inflammation. Then we have absolutely inflammation, and, lastly, loss of power, or paralysis. _Irritability of the Bladder._[3]—The chief indication of disease affecting the bladder is a frequent desire which the patient experiences to pass his water; but that symptom alone does not determine the nature of the complaint. It may be irritable from sympathy with surrounding irritation, and disappear on the subsidence of that irritation. It may constantly be fretting the patient by its contractions, through the urine (owing to some general derangement in the system, being altered in its chemical qualities) exciting the bladder the moment it is secreted therein; or it may be the result of nervous agitation, with or without any actual diseased state of the bladder. These causes should be understood to regulate the treatment, which of course must be qualified by the provocation, and which the patient, when in doubt, had better leave to the discrimination of his physician. _Paralysis of the Bladder._—The bladder may become, through loss of nervous stimulus, insensible to irritation, and consequently be disobedient to its natural functions. The urine, in these cases, accumulates in large quantities, distends the bladder to its utmost, which it does without pain; and the excess of secretion then dribbles away involuntarily. This state of the bladder is called paralysis, and is an aggravated form of disease, arising from the same causes that establish inflammation, or from some contiguous nervous injury. The treatment of paralysis of the bladder must be intrusted to experienced hands; it consists chiefly of purgatives, stimulative enemata up the rectum, the introduction of the catheter, the cold bath, rest, and general medicinal nervous excitants.