So far there was nothing to distinguish Alessandro Farnese from other ecclesiastics of the Renaissance. As Cardinal he seemed destined, should he ever attain the Papal dignity, to combine the qualities of the Borgian and Medicean Pontiffs. But before his elevation to that supreme height, he lived through the reigns of Julius II., Leo X., Adrian VI., and Clement VII. Herein lies the peculiarity of his position as Paul III. The pupil of Pomponius Laetus, the creature of Roderigo Borgia, the representative of Italian manners and culture before the age of foreign invasion had changed the face of Italy, Paul III. was called at the age of sixty-six to steer the ship of the Church through troubled waters and in very altered circumstances. He had witnessed the rise and progress of Protestant revolt in Germany. He had observed the stirrings of a new and sincere spirit of religious gravity, an earnest desire for ecclesiastical reform in his own country. He had watched the duel between France and Spain, during the course of which his predecessors Alexander V. and Julius II. restored the secular authority of Rome. He had seen that authority humbled to the dust in 1527, and miraculously rehabilitated at Bologna in 1530. He had learned by the example of the Borgias how difficult it was for any Papal family to found a substantial principality; and the vicissitudes of Florence and Urbino had confirmed this lesson. Finally, he had assisted at the coronation of Charles V.; and when he took the reins of power into his hands, he was well aware with what a formidable force he had to cope in the great Emperor. Paul III. knew that the old Papal game of pitting France against Spain in the peninsula could not be played on the same grand scale as formerly. This policy had been pursued with results ruinous to Italy but favorable to the Church, by Julius. It had enabled Leo and Clement to advance their families at the hazard of more important interests. But in the reign of the latter Pope it had all but involved the Papacy itself in the general confusion and desolation of the country. Moreover, France was no longer an effective match for Spain; and though their struggle was renewed, the issue was hardly doubtful. Spain had got too firm a grip upon the land to be cast off.