The wars between France and Spain revived the almost obsolete dispute, which the despots of the fifteenth century and the diplomatic confederation of the five great powers had tended in large measure to erase. The Guelfs and Ghibellines were now partisans of France and Spain respectively. Thus a true political importance was regained for the time-honored factions; and in the distracted state of Italy they were further intensified by the antagonism between exiles and the ruling families in cities. If Cosimo de'Medici, for example, was a Ghibelline or Spanish partisan, it followed as a matter of course that Filippo Strozzi was a Guelf and stood for France. Paul III. managed to maintain himself by manipulating these factions and holding the balance between them for the advantage of his family and of the Church. He thus succeeded in creating the Duchy of Parma and Piacenza for his son, Pier Luigi Farnese, that outrageous representative of the worst vices and worst violences of the Renaissance. It will be remembered that Julius had detached these two cities from the Duchy of Milan, and annexed them to the Papal States, on the plea that they formed part of the old Exarchate of Ravenna. When Charles decided against this plea in the matter of Modena and Reggio, he left the Church in occupation of Parma and Piacenza. Paul created his son Duke of Nepi and Castro in 1537, and afterwards conferred the Duchy of Camerino on his grandson, Ottavio, who was then married to Margaret of Austria, daughter of Charles V., and widow of the murdered Alessandro de'Medici. The usual system of massacre, exile, and confiscation had reduced the signorial family of the Varani at Camerino to extremities. The fief reverted to the Church, and Paul induced the Cardinals to sanction his investiture of Ottavio Farnese with its rights and honors. He subsequently explained to them that it would be more profitable for the Holy See to retain Camerino and to relinquish Parma and Piacenza to the Farnesi in exchange. There was sense in this arrangement; for Camerino formed an integral part of the Papal States, while Parma and Piacenza were held under a more than doubtful title. Pier Luigi did not long survive his elevation to the dukedom of Parma. He was murdered by his exasperated subjects in 1547. His son, Ottavio, with some difficulty, maintained his hold upon this principality, until in 1559 he established himself and his heirs, with the approval of Philip II., in its perpetual enjoyment. The Farnesi repaid Spanish patronage by constant service, Alessandro, Prince of Parma, and son of Ottavio, being illustrious in the annals of the Netherlands. It would not have been worth while to enlarge on this foundation of the Duchy of Parma, had it not furnished an excellent example of my theme. By this act Paul III. proved himself a true and able inheritor of those political traditions by which all Pontiffs from Sixtus IV. to Clement VII. had sought to establish their relatives in