The absorption of the silver into the system is slow, as the albuminoid and chlorine combinations formed in the intestinal canal cannot be immediately dissolved again. In the tissues the absorbed silver salt is decomposed by the tissues, and the oxide and metallic silver separate. Partly for this reason and partly on account of the formation of the solid albuminates, etc., the elimination of the silver from the body takes place very slowly. Some of the silver, however, passed out in the fæces, and, according to Lauderer, Orfila, and Panizza, some can be detected in the urine. Bogolowsky[1] has also shown that in rabbits poisoned with preparations of silver, the (often albuminous) urine and the contents of the (very full) gall bladder contained silver. [Footnote 1: Arch. f. Path. Anatomie, xlvi., p. 409. Gaz. Med de Paris, 1868, No. 39. Also Journ. de l'Anatomie et de la Physiologie, 1873, p. 398.] Mayencon and Bergeret have also shown that in men and rabbits the silver salt administered is quickly distributed in the body, and is but slowly excreted by the urine and fæces. Chronic poisoning shows itself in a peculiar coloring of the skin (Argyria Fuchs), especially in the face, beginning first on the sclerotic. The skin does not always take the same color; it becomes in most cases grayish blue, slaty sometimes, though, a greenish brown or olive color. Von Hasselt thinks that probably chloride of silver is deposited in the rete malpighii, which is blackened by the action of light, or that sulphide of silver is formed by direct union of the silver with the sulphur of the epidermis. That the action of light is not absolutely necessary, Patterson states, follows from the often simultaneous appearance of this coloring upon the mucous membrane, especially that of the mouth and upon the gums; and Dr. Frommann Hermann[1] and others have shown that a similar coloring is also found in the internal parts. [Footnote 1: Leh der Experiment. Tox. Dr. Hermann, Berlin, 1874, p. 211.] Versmann found 14.1 grms. of dried liver to contain 0.009 grm. chloride of silver, or 0.047 per cent. of metallic silver. In the kidneys he found 0.007 grm. chloride of silver, or 0.061 per cent. of metallic silver; this was in a case of chronic poisoning, the percentage will be seen to be very small. Orfila Jun. found silver in the liver five months after the poisoning. Lionville[1] found a deposit of silver in the kidneys, suprarenal gland, and plexus choroideus of a woman who had gone through a cure with lunar caustic five years before death. [Footnote 1: Gaz. Med., 1868. No. 39.] Sydney Jones[1] states that in the case of an old epileptic who had been accustomed to take nitrate of silver as a remedy, the choroid plexuses were remarkably dark, and from their surface could be scraped a brownish black, soot-like material, and a similar substance was found lying quite free in the cavity of the fourth ventricle, apparently detached from the choroid plexus.