[Footnote 1: Trans. Path. Soc., xi. vol.] Attempts at poisoning for suicidal purposes with nitrate of silver are in most cases prevented from the fact that this salt has such a disagreeable metallic taste as to be repulsive; cases therefore of poisoning are only liable to occur by accident or by the willful administration of the poison by another person. Such a case occurred quite recently, to a very valuable mare belonging to August Belmont. I received on Dec. 6, 1882, a sealed box from Dr. Wm. J. Provost, containing the stomach, heart, kidney, portion of liver, spleen, and portion of rectum of this mare for analysis. Dr. Provost reported to me that the animal died quite suddenly, and that there was complete paralysis of the hind quarters, including rectum and bladder. The total weight of the stomach and contents was 18 lb., the stomach itself weighing 3 lb. and 8 oz. Portions were taken from each organ, weighed, and put in alcohol for analysis. The contents of the stomach were thoroughly mixed together and measured, and a weighed portion preserved for analysis. The stomach, when cut open, was perfectly white on its inner surface, and presented a highly corroded appearance. The contents of the stomach were first submitted to qualitative analysis, and the presence of a considerable quantity of nitrate of silver was detected. The other organs were next examined, and the presence of silver was readily detected, with the exception of the heart! The liver had a very dark brown color. A quantitative analysis of the contents of the stomach gave 59.8 grains of nitrate of silver. In the liver 30.5 grains of silver, calculated as nitrate, were found (average weight, 11 lb.). From the analysis made there was reason to believe that at least one-half an ounce of nitrate of silver was given to the animal. Some naturally passed out in the fæces and urine. I was able to prepare several globules of metallic silver, as also all the well known chemical combinations, such as sulphide, chloride, oxide, iodide, bromide, bichromate of silver, etc. From the result of my investigation I was led to the conclusion that the animal came to death by the willful administering of nitrate of silver, probably mixed with the food. The paralysis of the hind quarters, mentioned by Dr. Provost, accords perfectly with the action of this poison, as it acts on the nerve centers, especially the cerebro-spinal centers, and produces spasms of the limbs, then of the trunk, and finally paralysis. I might also state in this connection that, only two weeks previous to my receiving news of the poisoning of the mare, I examined for Mr. Belmont the contents of the stomach of a colt which died very mysteriously, and found large quantities of corrosive sublimate to be present. Calomel is often given as a medicine, but not so with corrosive sublimate, which is usually employed in the arts as a poison.