Scientific American Supplement, No. 611, September 17, 1887Various
Science
Scientific American Supplement, No. 611, September 17, 1887
Various
Science -- Periodicals
A fair quantity of the urine, after shaking, should be placed in a
tall conical glass vessel, to allow easy collection of the precipitate
for subsequent, microscopical examination. If an abundant amorphous
deposit of a fawn or pink--from _uroerythrin_--color slowly settles
and is readily diffused, _urates_ in excess can be anticipated. Their
presence is proved by the readiness with which they dissolve on
warming with the supernatant urine to about the temperature of the
blood. No difficulty is experienced if small quantities of albumen are
present, as that body is not coagulated until the temperature rises
much higher. A sandy precipitate of free _uric acid_ will not dissolve
on warming the urine, and its identity can further be determined by
means of the microscope, or by applying a well-known color-reaction. A
grain or so is oxidized into reddish alloxan and alloxantin by
carefuly evaporating with a few drops of strong nitric acid on a piece
of porcelain. A little ammonia is then added, when the fine _purple_
murexide stain will be produced.
It is always advisable to mention the reaction to test papers of all
samples received. Urine is normally _acid_, but there are certain
diseases which render fluid neutral or alkaline. The urea of acid
urine on standing is changed by a putrefactive ferment into ammonic
carbonate, but this decomposition in a state of health should not
take place for at least twenty-four hours. Alkalies, or organic salts
of alkaline metals, when taken as medicine render the urine alkaline,
and the indication is then not of much moment; but if none of these
causes exist, the condition is of serious diagnostic import. Where it
is desired to determine the degree of acidity of the urine voided,
say, by a gouty patient, a dilute volumetric solution of caustic soda
should be employed, using a few drops of an alcoholic solution of
phenolphthalein as an indicator, and reporting in terms of oxalic
acid. The soda solution may conveniently contain the equivalent of one
milligramme of recrystallized oxalic acid (H_{2}C_{2}O_{4}.2H_{2}O) in
each cubic centimeter.
UREA.
Carbamide, as it is called by systematic chemists, or _urea_, is next
to water the largest constituent of urine, and forms about one-third
of its total solids. Derived from ammonic carbonate by abstracting two
molecules of the elements of water, it is readily converted by
putrefaction into that salt, and the urine under these circumstances
becomes strongly alkaline in reaction. Earthy phosphates then fall
naturally out of solution, so that the putrid fluid is always well
furnished with sediment. Nitrogen that has served its purpose as
muscle or other proteid leaves the animal economy chiefly in the form
of urea, and its proportion in the urine, therefore, is a fair index
of the activity of wasting influences.
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