Opium and its alkaloid, morphia, are so commonly used in the practice of medicine that the poisonous result of an overdose is not uncommon. The common preparations are gum opium, the inspissated juice of the poppy; powdered opium, made from the gum; tincture of opium, commonly called laudanum; and the alkaloid or active principle, morphia. Laudanum has about one-eighth the strength of the gum or powder. Morphia is present in good opium to the extent of about 10 per cent. In medicine it is a most useful agent in allaying pain. It first produces a stimulating action, which is followed by drowsiness, a disposition to sleep or complete anesthesia, depending on the quantity of the drug used. In poisonous doses a state of exhilaration is well marked at first. This is particularly noticeable in cattle and in horses. The animal becomes much excited, and this stage does not pass into insensibility unless an enormous dose has been given. If the dose is large enough, a second stage sometimes supervenes, in which the symptoms are those of congestion of the brain. The visible membranes have a bluish tint (cyanotic) from interference with the air supply. The breathing is slow, labored, and later stertorous; the pupils of the eyes are very much contracted; the skin dry and warm. Gas accumulates in the stomach, so that tympanites is a prominent symptom. The patient may be aroused by great noise or the infliction of sharp pain, when the breathing becomes more natural. A lapse into the comatose condition takes place when the excitement ceases. Later, there is perfect coma and the patient can no longer be aroused from the insensible condition. The contraction of the pupil becomes more marked, the breathing intermittent and slower, there is perspiration, the pulse more feeble and rapid, till death takes place. Poisoning of cattle with opium or its products rarely goes beyond the stage of excitement, because the quantity of the drug required for the later effects is so great. Seventy-five grains of morphia administered subcutaneously has sufficed merely to excite for 12 hours. _Treatment._--Give strong coffee, 1 to 4 quarts, aromatic spirits of ammonia or carbonate of ammonia. Atropia is the physiological antidote. STRYCHNIN POISONING.