The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economyHeadland, Frederick William
Science
The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economy
Headland, Frederick William
Therapeutics
or, Oil of Turpentine, with the addition of three atoms of Oxygen,
produces Pinic acid, _i.e._ Resin, and an atom of water.
Now Turpentine, when given in large quantities, irritates the surface of
the intestinal canal in man, and is not absorbed. But in the horse very
large doses are found to pass through the system into the urine. It is
not likely that a large quantity should enter in solution in water. It
seems more probable that it may first in some way become oxidized, and
then dissolved as a resin. The action of turpentine resembles that of
some other substances which contain resin, as Copaiba and Balsam of
Peru.
The resins thus dissolved would pass, like other solutions, through the
mucous membrane of the intestines into the Portal capillaries.
But of the fats and fixed oils it cannot be said to be _proved_ that
they are absorbed in a state of solution, although such a conclusion is
almost forced upon us by a consideration of the laws of endosmosis. They
do not pass into the veins, but are taken up by the lacteal absorbents.
They are _capable of solution_, and are thus not in that sense an
exception to the rule of Prop. II. But in another sense they are an
exception to it; for they do not pass directly into the veins, but
through the lacteal system. It seems that the sole purpose of these
lacteal vessels is to absorb fats. Thus it appears that all soluble
substances, whether in the food or given as medicine, and in whatever
manner rendered soluble, whether by acid, by alkali, or by stomach
digestion, are absorbed in the stomach and intestines. All of them, with
the exception of fatty matters, pass directly into the blood, traversing
the mesenteric and Portal veins, to reach the liver. From this organ
they pass on into the heart through the Vena cava inferior. I have shown
also that they are mostly absorbed without material change. Supposing
the stomach acid to be lactic, it would be too weak to displace mineral
acids. It would, however, decompose a few insoluble matters, and
combine with alkalies and their carbonates, forming salts which in the
blood would again change into carbonates. (_Vide_ Prop. VI.)
PROP. III.--_That those medicines which are completely insoluble in
water, and in the gastric and intestinal juices, cannot gain entrance
into the circulation._
It may at first sight be objected to this proposition, that fatty
matters may probably enter the lacteals in an undissolved state. But
this is not proved; and besides, whether dissolved or not, we know that
they are soluble in one at least of the intestinal juices--viz. the
Bile. So that they do not come under the above definition.
Public-domain text, read in full here on John Shaqi.
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